Smith leads the NFL in passing yards through five weeks. The 49ers have been stout against the run, so I expect the Seahawks to continue leaning on their passing attack on Thursday night. Smith has a great group of pass catchers at his disposal, and if San Francisco jumps ahead, this could easily turn into another 275+ yard performance for the former West Virginia quarterback.

Seattle may very well have the best three wideout tandem in football with DK Metcalf, Jaxon Smith-Njigba, and Tyler Lockett. Lockett has been consistent outside of a fifteen yard performance against the Patriots. In fact, he has went over tonight’s set number in four out of five games this season. Divisional games on a short week tend to be lower scoring, but look for the Seahawks to have enough successful drives for Lockett to clear his prop once again. Take his over.

I don't typically like playing the moneyline at this type of price, but that extra hook on the spread makes me uneasy. Weird things have been known to happen on Thursday Night Football, so I'm going to play it safe and take the 49ers to win straight up against a banged up Seattle team that has lost two straight.

The 49ers are still without Christian McCaffrey, but Jordan Mason has filled in admirably. San Francisco's red zone woes worry me some, but this pick is more about Seattle's struggles on the defensive side of the ball. The Seahawks gave up 42 points to the Lions and 29 to the Giants in their last two games. I like the Niners' chances at hitting 27+ here.

Despite their coach's defensive mindset, the Seahawks have performed below expectations. Seattle allowed 42 points to the Lions and 29 to the Giants in consecutive losses, and it even gave up plenty to the offensively challenged Broncos and Patriots. The 49ers have the opposite issue: converting in the red zone. San Francisco has struggled finding pay dirt, but it should help that Seattle is injured and tired (third game in 11 days), plus Brock Purdy is 4-0 in his career against the Seahawks. Look for the Niners to capitalize as the more disciplined and rested team. Wish I jumped on this earlier in the week at -3 (would still prefer that at -120 or better, if available for you).

The tricky hook on the key number could come into play between NFC West rivals with plenty at stake. Seattle is looking to avoid a third straight loss, while San Francisco dropping to 2-4 would be a disaster for its playoff hopes. The 49ers have been beset by some late-game misfortune and hampered by injuries. But they are still the far superior team. They swept Seattle last year by a combined score of 59-29 and the gap between them remains just as wide. This is a pretty cheap price to avoid sweating the ATS outcome.

Both teams can score in this matchup, but they also both play solid defense. The 49ers still have one of the league's best defenses, while the Seahawks' are led by one of the game's top young defensive minds (Mike Macdonald). I think there will be some scoring in this game, but I think it will take some time for these offenses to get into a groove.

I've been riding these kickers in prime time games all season, and I'm going to keep it going on TNF. Myers is 8-11 through five games, meaning the attempts are there for this pick to hit. I've been paying a much higher price for these field goal props all year, so I'll jump on this at -109.

Geno Smith leads the league in completions, pass attempts and passing yards through five weeks while completing 71.9% of his passes, and with the 49ers defense looking vulnerable, I see him having another big game here. He's had at least 284 yards in four straight and thrown fewer than 40 passes just once (against a Dolphins team that couldn't move the ball). He'll need to keep airing it out if the Seahawks want to keep up with a prolific 49ers offense that should have a field day against a beat-up Seattle defense, and I think he will. Also like taking the alt line on 300+ for this prop where available.

Is this going to be a higher-scoring affair tonight in Seattle? Maybe not. Geno Smith not having a real big year thus far for Seattle, with just 5 TDP in five games, though a bigger storyline is what might be wrong with the Niners, only 2-3 into tonight. An easy answer is the ongoing absence of Christian McCaffrey, an impact that is now starting to be felt, especially in the red-zone, when Brock Purdy's options seem more limited, and most plays end up flushing him out of the pocket to the sideline for low-percentage throws. The Niners have scored TDs via a pick-six and blocked FG return in the past two games...hard to replicate. Note both meetings landed on 44 last year. Play 49ers-Seahawks Under

The Seahawks enter this game with three key defenders ruled out and another three questionable, and that's a blueprint for a 49ers offensive explosion in primetime. Two weeks ago, a beat-up Seattle defense couldn't stop a single Jared Goff pass en route to the Lions scoring 42 points, and while the Giants' 29 points last week was boosted by a late blocked FG return, they also should've had another TD early on the coin-flip fumble at the goal line. The 49ers offense is one of the best in the league, and it may be pressed to keep scoring if the defense continues to struggle. I love San Francisco getting over this total tonight.

We got a buy low spot on Kyle Juszczyk. Last week he had no targets, but prior to that he had in 6 games: 15 targets (at least 1), 11 rec, 143 yards. With a 10.6 yards per reception average this is really an over/under 0.5 a reception bet. The Sportsline model makes the number 17.

This is a great spot for Purdy to capitalize on the touchdown dip he's experienced through 5 weeks. He's only had one game thus far with more than one touchdown pass, but he has been slinging the ball downfield and piling up yardage. This will be a high scoring matchup against a Seattle secondary that is banged up and a defense that got torched recently by Jared Goff and Daniel Jones. Purdy has all is weapons healthy and should showcase more efficiency in the red zone tonight. Expect SF to stay aggressive in the redzone, even if they are ahead late, in an effort to avoid squandering another lead.

The Seahawks pass-happy offense and vaunted WR trio may entice bettors towards the Over in this matchup. However, the 49ers quietly have one of the league’s best pass defenses through the first five weeks. Seattle’s offensive line is missing perhaps their best player, Tackle George Fant. His backup has struggled mightily, and will likely have the tall task of blocking Niners monster DE Nick Bosa. Don’t be surprised if the Seahawks look to establish the run game here more than in weeks past, considering their injuries and brutal scheduling. Similarly, I expect the Niners to control the line of scrimmage with a heavy dose of RB Jordan Mason. Chew up that clock! I’ll play this Under above the key number of 49.

This is a must-win game for the 49ers, as they will be favored to miss the playoffs if they lose. Despite their three losses, the 49ers still rank 4th in the NFL in Net EPA per drive at 0.72. San Francisco should dominate time of possession against a Seattle team that looks slightly inflated after a relatively soft start to the season. My simulations set the line on the other side of 5 on the short week. I played -3.5 +100 which is a better price than -3 (-125) that is also available. -3.5 +100 is equal to -3 (-119).

Kenneth Walker is healthy and showing his ridiculous burst. With Seattle in catch-up mode the past two weeks, Geno Smith targeted Walker 13 times. Walker is definitely going to get more than the five carries he received last week, but I also expect him to continue his excellence as a pass-catcher. "Got to get the ball to Ken more," OC Ryan Grubb told reporters this week.

The only time that Purdy has been below, this number has been when a) when the 49ers blew out the Jets and ran more than they threw and b) When Purdy only completed 54% of his passes and still fell less than 5 yards short! Unless we get a very unusual game script, this should go over.

In crunching Seattle’s offensive numbers, they exclusively throw the ball when they are behind, but definitely become an “even Steven” team in close games or if they are ahead. I’ll play against them being down big early and play Walker over.

This is a brutal scheduling spot for the Seahawks who played on Monday Night Football just two weeks ago, and now must quickly turn around for a short week Thursday game. Their injury-ridden defense gave up 29 to the New York Giants. Although the 49ers have not looked like the powerhouse team most expected thus far, this seems to be great “get right” spot. I will grab the flat -3 line while it is still available.

The 49ers will be shooting for big plays in their pass game, and Seattle needs to keep pace. Geno only had about 60 passing yards deep in the first half last week vs tricky D, and still ended up with 284, his lowest total of the season. SF 23 in yards/attempt allowed, and while Geno hasn't put up big numbers vs them int he past, his WRs are healthy and ready. Passing at least 34 times a game, leading NFL in pass yards.

I'm fading the 23+ points from Seattle on the short week against a division rival. This is a massive game for both teams, not only for the division but also for playoff consideration. I like the matchup for the 49ers' defense in what should be viewed as a must-win game for them, with Kansas City and Dallas coming up. Seattle has been fortunate to face relatively weak quarterback play to start the season, but Purdy and the 49ers should be able to dominate time of possession and keep Seattle in check.

The thing about Seattle is that their defense is simply a bad unit right now. They have benefited from playing rookies and back ups in their first three games. But since then they gave up 42 to Detroit and 29 last week to Daniel Jones (without M Nabers). And SF ‘s O has Struggled at times… But they still have experienced elite playmakers.

Seahawks injuries are probably a far greater factor in this game than the 49ers much talked about absences. Seattle compromised at the line of scrimmage on both sides of the ball and 49ers will be hungry for a win here. SF still running ball effectively and Brock Purdy has a 109.2 passer rating vs SEA. Mike Macdonald had the secret sauce for stopping Kyle Shanahan and his family tree in Baltimore but already got shredded by Jared Goff this year and Purdy and Shanny out for revenge. Geno Smith might be under siege here. SF is 10-5-1 ATS vs NFCW on road since '19. SEA 6-9 ATS at home in division in that span. Hawks just 4-5-2 ATS at home since start of '23.

In their 3-0 start, the Seahawks faced Bo Nix making his NFL debut, Jacoby Brissett and Skylar Thompson. More talented QBs, Jared Goff and Daniel Jones, combined to complete 41 of 52 throws with four TDs and no INTs. Brock Purdy definitely falls in the latter category and he'll be facing an injury-depleted Seattle defense. Top cornerback Riq Woolen left the Giants' game with an ankle injury and was listed as 'did not practice' Monday. This will be Seattle's third game in 11 days, and I don't expect the Seahawks to be able to keep up.

The Seahawks 3-2 record is a little inflated because of their early schedule that consisted of Denver, New England, and a Miami squad without a quarterback. The only game they've covered the season was against Miami without a quarterback. The last two games look like who they are, Seattle losing 42-29 to the Lions and also 29-20 to the Giants. In that Giants game, it was puzzling to see only 11 runs, four of them by Geno Smith, and 40 passes. They completely abandoned the run game and they had both Kenneth Walker and Zach Charbonnet available. The new coach is second-guessing himself. The 49ers have won five straight times over the Seahawks and they'll do it again despite their sluggish play lately. 49ers cover.