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Fri, Nov 241:20 am UTCLumen Field
39 F
Track OnCBS Sports
San Francisco
49ers
SF
Last 5 ATS
W/L12-5
ATS9-8
O/U9-7-1
FINAL SCORE
31
-
13
Seattle
Seahawks
SEA
Last 5 ATS
W/L9-8
ATS8-7
O/U7-10-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
12-5
Win /Loss
9-8
9-8
Spread
8-7
9-7-1
Over / Under
7-10-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
SF @ SEA
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Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

MONEYLINE
SF @ SEA
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OVER / UNDER
SF @ SEA
Subscribers Only

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82%
PUBLIC
18%
MONEY
88%
PUBLIC
12%
MONEY
Over50%
PUBLIC
Under50%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Avatar
Total Rushing YardsElijah Mitchell Under 17.5 Total Rushing Yards -123
LOSS
Unit0.5
Josh's Analysis:

The bruising 49ers backup RB has clipped this number the past two weeks, aided by a 13-yard gain last week. But Mitchell's 47 combined yards the past two weeks cam in mop-up duty in blowouts. In competitive game scripts, he rarely sees the field. Unless the 49ers pull away late or Mitchell cracks another decent run with limited touches, he is likely to revert to his role as a seldom-seen backup to Christian McCaffrey. .

Pick Made: Nov 23, 11:51 pm UTC on WilliamHillNewJersey
Point SpreadSan Francisco -7 -108
WIN
Unit1.0
+2294
84-55-8 in Last 147 NFL ATS Picks
+723
16-8-1 in Last 25 SF ATS Picks
Adam's Analysis:

Despite being at home on Thanksgiving, which is a motivator for any team, the Seahawks are in a tough spot here starting with Geno Smith being seriously banged up. While Zach Charbonnet has been impressive, there's a reason Kenneth Walker III is the bell-cow back (he's out). The 49ers are a different offense with Deebo Samuel healthy, and while I like them to put up four touchdowns, I'm not sure the Seahawks will be able to hang more than a couple. Plus, the Niners have won three straight head-to-head by double digits. I'll take the healthier, fresher, better team on a short week.

Pick Made: Nov 23, 5:39 am UTC on DraftKings
Avatar
Total Receiving YardsZach Charbonnet Over 19.5 Total Receiving Yards -125
LOSS
Unit1.0
+515
36-25 in Last 61 NFL Player Props Picks
Sia's Analysis:

Rushing the ball against the 49ers doesn't usually work out well, but they are somewhat vulnerable to RBs coming in the pass catching department. With Kenneth Walker out I expect Charbonnet to have the 3-down role but it'll be the receptions that keep him productive. The 49ers can also create a lot of pressure with their front four so expect a lot of dump offs or check downs to Charbonnet.

Pick Made: Nov 23, 3:33 am UTC on WilliamHillNewJersey
Point SpreadSan Francisco -7 -105
WIN
Unit1.0
+558
19-12-2 in Last 33 NFL Sides Picks
+258
16-12-2 in Last 30 NFL ATS Picks
+2238
29-6 in Last 35 SF ATS Picks
Micah's Analysis:

The 49ers average a 27-15 score on the season but are only 5-5 ATS. Their three losses on the season stalled their momentum, but those three games were without Deebo Samual and more importantly Trent Williams (both hurt at Cleveland). So the games they didn’t cover with Williams were a fluke field goal at the end of the win over the Rams in Week 2 (30-23) and the Week 11 win over the Buccaneers (27-14) against the closing number (+13.5). The 49ers didn’t cover two games by a half-point each or they’d be 7-0 ATS behind a healthy Williams and Samuels. 49ers to cover.

Pick Made: Nov 22, 11:05 pm UTC on Bet365NewJersey
Avatar
Total Receiving YardsGeorge Kittle Over 52.5 Total Receiving Yards -115
LOSS
Unit1.0
+1375
43-25 in Last 68 NFL Player Props Picks
Jason's Analysis:

Kittle had a slow start but looks to be as healthy and spry as he's been in a long time, and with Trent WIlliams back Brock Purdy can boot and waggle and hold the ball for a while, which is when he and Kittle tend to hook up downtield. Kittle has 78 rec yards or more in 4 in a row, and Seattle allows 7.7 y/att to TEs (7th worst in NFL) with 76% completions. Kittle caught 4 of 5 targets for 94 yards and 2 TDs at Seattle last Dec in Purdy's big road start there. Wouldn't be shocked to see him get close to 10 targets in this game finding seams in Cover 3.

Pick Made: Nov 21, 9:28 pm UTC on WilliamHillNewJersey
Avatar
Total Rushing + Receiving YardsChristian McCaffrey Over 112.5 Total Rushing + Receiving Yards -118
WIN
Unit1.0
+1375
43-25 in Last 68 NFL Player Props Picks
Jason's Analysis:

He owns Seattle, with 686 scrimmage yards in 4 games against the Seahawks. He had 17 touches for 136 against them in the playoffs and 32 touches for 138 yards with the 49ers against Seattle. Last season when SF and SEA met prior to the CMC trade, the 49ers still rank up 189 rushing yards on 45 carries. With a chance to put away Seattle here for the divisional race, and with a lot of rest ahead and a few weeks removed from a bye, I think Kyle Shanahan lets his best guy see a ton of the ball here.

Pick Made: Nov 21, 9:15 pm UTC on WilliamHillNewJersey
Point SpreadSan Francisco -6.5 -110
WIN
Unit1.0
+2450
202-148-2 in Last 352 NFL Picks
+1754
79-55-2 in Last 136 NFL ATS Picks
+1075
32-19-4 in Last 55 SEA ATS Picks
Larry's Analysis:

The 49ers beat Seattle three times last season by a combined 89-43. They're 2-0 since their bye, with emphatic wins over the Jaguars and Buccaneers. San Francisco ranks second in yards per play (6.4) and sixth in yards per play allowed (4.9). Geno Smith is expected to play through his elbow injury, but this is a difficult matchup against a 49ers' defense boosted by Chase Young's arrival. 49ers rookie safety Ji'Ayir Brown did an admirable job replacing injured All-Pro safety Talanoa Hufanga last week, breaking up two potential TD passes and snagging an interception. Lay the points before this number climbs.

Pick Made: Nov 21, 6:40 pm UTC on Bet365NewJersey
Total Away PointsSan Francisco Over 24.5 Total Pts -110
WIN
Unit1.0
+75
2-1 in Last 3 NFL Team Props Picks
Jason's Analysis:

Brock Purdy has been basically perfect in two games since Trent Williams returned at LT. They can thrash you on the ground and through the air and this Seattle D is shaky. They've faced largely suspect offenses but DET (31 pts), BAL (37), WSH (26) have topped this number. Seattle is 29th in 3rd Down D and 28th in the RZ. Bad combo vs this unit. SF pass rush will be a problem, especially if Drew Lock plays any of this game; will set up the offense with short fields. Aiyuk, Kittle and CMC are all humming, putting too much strain on the Seahawks. 49ers average 28/G. Topped this number twice vs Seattle in '22 (including playoffs).

Pick Made: Nov 21, 1:34 am UTC on WilliamHillNewJersey
Point SpreadSeattle +7 -110
LOSS
Unit0.5
+1249.5
64-48-5 in Last 117 NFL Sides Picks
+85
2-1 in Last 3 NFL ATS Picks
+1255
23-10 in Last 33 SEA ATS Picks
Josh's Analysis:

The Seahawks have lost two of their past three after letting a game they controlled most of the way slip away against the Rams on Sunday. Now, they face brutal stretch that includes two meetings with San Francisco sandwiched around a visit to Dallas. Lose all three and they are a longshot to make the playoffs. Ailing QB Geno Smith is expected to play, and rookie Zach Charbonnet will take the RB1 role for the injured Kenneth Walker. It looks dire against a surging 49ers club, but look for the Seahawks to do enough to cover the key number as a desperate home underdog.

Pick Made: Nov 20, 9:37 pm UTC on Bet365NewJersey
Point SpreadSan Francisco -6.5 -115
WIN
Unit1.0
+2338.5
59-32 in Last 91 NFL Picks
+1169
13-3 in Last 16 NFL ATS Picks
+535
7-1 in Last 8 SF ATS Picks
Jason's Analysis:

Geno Smith missed time Sunday and just came back very late. They are cooked with Drew Lock (or Geno frankly) against a 49ers defense with its swagger and menace back after the bye and the Chase Young trade. Kenneth Walker was also lost on Sunday and this is a very quick turnaround. Seattle’s record has always flattered them and they are getting San Francisco at the worst possible time. San Francisco swept the Seahawks last year (27-7 at home and 21-13 at Seattle), and this feels more like 27-16 to me. Brock Purdy excelled in his first game facing The 12th Man in Seattle late last season, which will only help him this time around. Purdy playing like an MVP again with Trent WIlliams back.

Pick Made: Nov 20, 3:42 am UTC on FanDuel

Team Injuries

San Francisco 49ers
Monday, May 05, 2025
Avatar
QB
Kurtis Rourke
KneeQuestionable
Thursday, May 01, 2025
Avatar
OT
Trent Williams
AnkleQuestionable
Avatar
OT
Colton McKivitz
UndisclosedQuestionable
Avatar
P
Mitch Wishnowsky
BackQuestionable
Avatar
CB
Deommodore Lenoir
ShoulderQuestionable
Avatar
CB
Tre Brown
KneeQuestionable
Avatar
DE
Robert Beal Jr.
AnkleQuestionable
Avatar
DB
George Odum
KneeQuestionable
Avatar
OT
Spencer Burford
CalfQuestionable
Avatar
RB
Isaac Guerendo
Knee - MCLQuestionable
Avatar
DE
Drake Jackson
KneeQuestionable
Avatar
CB
Renardo Green
GroinQuestionable
Avatar
CB
Darrell Luter Jr.
PelvisQuestionable
Wednesday, Apr 30, 2025
Avatar
SAF
Malik Mustapha
Knee - ACLQuestionable
Wednesday, Feb 12, 2025
Avatar
WR
Brandon Aiyuk
Knee - ACL + MCLQuestionable
Seattle Seahawks
Thursday, May 01, 2025
Avatar
DE
DeMarcus Lawrence
FootQuestionable
Avatar
CB
Tariq Woolen
RibsQuestionable
Avatar
OT
Abraham Lucas
AbdomenQuestionable
Avatar
RB
Kenneth Walker III
AnkleQuestionable
Avatar
SAF
Jerrick Reed II
QuadricepsQuestionable
Avatar
OG
Anthony Bradford
AnkleQuestionable
Avatar
DT
Byron Murphy II
BackQuestionable
Wednesday, Mar 26, 2025
Avatar
LB
Uchenna Nwosu
KneeQuestionable

Season Splits

All Games
ALL
All Games
50%
5-5
6-4
60%
On Road
LOCATION
At Home
40%
2-3
3-2
60%
As Favorite
STATUS
As Underdog or PK
50%
5-5
2-2
50%
When Spread was -8.5 to -5.5
SPREAD
When Spread was +5.5 to +8.5
0%
0-2
0-1
0%
As Road Favorite
LOCATION & STATUS
As Home Underdog
40%
2-3
0-0
0%
vs Teams That Win >55% of Games
OPP WIN%
vs Teams That Win >55% of Games
67%
2-1
2-1
67%
vs Teams Allowing 21 to 25 PPG
OPP DEFENSE
vs Teams Allowing <21 PPG
33%
1-2
2-1
67%
After <=8 Days Off
REST
After <=8 Days Off
29%
2-5
6-2
75%
vs SEA
HEAD TO HEAD
vs SF
0%
0-0
0-0
0%
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