It hurts to have lost the best line on this game, but given how many close contests these teams have played, 2.5 points is better than none. I'm taking Seattle in this case because I believe there's an excellent chance it wins outright on the road. There's nothing offensively about the 49ers I believe in. Even just one strong half from the Seahawks could, theoretically, be enough to eek out a win. Given the weapons and clear quarterback advantage, I'm happy to roll with Seattle leading a team that badly needs a win.

Throughout Seattle QB Russell Wilson’s career, he has been able to respond when the adversity is high. The Seahawks' losses this season came against Tennessee and Minnesota teams that were hungry for a win. Expect Wilson to perform better on the road and get Seattle playing at the level we expect.

Taking an underdog at 2.5 points is often ill-advised. Only do so if you are convinced the 'dog will win outright. Seattle outgained Minnesota and Tennessee significantly the last two Sundays. Injuries have rippled through the 49ers, and the most critical area is the secondary. Seahawks WRs DK Metcalf and Tyler Lockett each had massive games against San Francisco a year ago and could run unfettered on pass routes. No team better exemplifies the decline of home-field advantage. The Niners have dropped five in a row outright at Levi’s Stadium.

I love fading Kyle Shanahan and the 49ers as home favorites. Since Shanahan took over the team, the 49ers are only 5-12-1 ATS as home favorites, and 3-12-1 ATS as home favorites during the regular season. Now, a week after blowing it late against the Packers, the Niners are hosting a Seattle team that cannot afford a 1-3 start to the season in the NFL's most competitive division.

Neither of these teams seem to be able to put together a full 60 minutes. For the second week in a row, the 49ers offense got nothing done until the waning moments of the first half, while the Seahawks offense continues to sputter in the second half. I guess that means we're firing on Seattle in the first half and San Francisco on the live line, right? As for the full game, I just can't see the Seahawks dropping three in a row, and I'll continue to back their excellent ATS record coming off a loss, even if it didn't come in last week. Watch the injury report with George Kittle and Tyler Lockett nursing injuries, but I think the Seahawks are value at +3.