Both teams are looking for bounce-back efforts here in a tough spot as competing top-tier units are going against one another. The 49ers are getting some key defensive reinforcements back, while the Chiefs are making a much-needed change at running back that should help their offense find more consistency. San Francisco is garnering a lot of love early this season, but for what, exactly? Beating up on Carolina and Seattle? Losing to Chicago, Denver and Atlanta? The Chiefs have been tested frequently through the first third of the season and have the quarterback I trust more to pull out a win late in Patrick Mahomes.

Forget about Christian McCaffrey — it’s unclear if he’ll even play. The big 49ers additions here are players they already had, as Nick Bosa, Trent Williams and Jimmie Ward were not on the injury report. It makes this a much different Niners team from Week 6, with arguably their two best players in Bosa and Williams back on the field. Of course, they’ll be facing Patrick Mahomes, but the Chiefs are a low-key 1-4 ATS in their last five. This line was below a field goal even before the McCaffrey trade, and I think the Niners get a win at home. Grab the point.

The acquisition of Christian McCaffrey has caused a slight dip in this spread, though it's unclear if and how much he'll play. The versatile back for sure would make the 49ers more potent, but this doesn't negate the value on the Chiefs. They are at their best following a subpar performance, as they showed with a road blowout of Tampa Bay following their upset loss to the Colts. The 49ers could bounce back from their upset loss to Atlanta, but the value price on KC is too good to pass up.

The 49ers come off a bad loss at Atlanta, but they’re 6-0 ATS in their last six against a winning team. The defensive line was banged up against the Falcons, but Nick Bosa practiced this week and is expected to play. The defense bounces back here against one of the best offenses. The 49ers have stayed Under in their last six after a loss. The Chiefs are 1-4 ATS in their last five games, playing below their high rating. I think we get the whole 49ers offensive package at home here, and that doesn’t include new RB Christian McCaffrey who I don’t expect to play much. Jimmy G, George Kittle, and Deebo Samuel get the job done here. 49ers to cover.

Both these teams enter this week off disappointing losses, though Kansas City's came as underdogs against the best team in the league. The 49ers' injuries appeared to catch up with them against Atlanta, and even if they're a little healthier this week, I like the Chiefs in this spot. Kansas City's offense is great on third down and in the red zone, where the 49ers are just good despite their No. 1 overall ranking in yards per play. Even though it feels like the Chiefs defense is struggling against the run, they rank sixth in yards per play there, so it's possible this game falls on Jimmy Garoppolo's shoulders to keep up with Patrick Mahomes and Co. I'd grab the Chiefs if you can get them under a field goal and expect a nice bounce-back this week.