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The Hoosiers have only lost once at Assembly Hall, and that was by four points to Kansas. Indiana has beaten Purdue in three of four tries under Mike Woodson. The Boilermakers have been vulnerable on the road. Look for a narrow Purdue win.
Quick disclaimer: I went to Indiana but this pick is (hopefully) unbias. Ranked teams are just 40-47 straight up on the road this season. The Hoosiers are 25-3 SU at home in the last two seasons, including a win over then #1 Purdue. The Hoosiers have been great against Purdue in the last three seasons going 3-1 SU & 4-0 ATS. Purdue is just 1-2 SU on the road this season with losses at unranked Northwestern and unranked Nebraska. This spread is way too big for a rivalry of this magnitude. Take the Hoosiers.
Big number for a road rivalry game and Mike Woodson has had Purdue's number in Bloomington. The Boilers have played three true road games and lost two of them. Indiana has perhaps the size to at least limit Zach Edey with the likes of Malik Reneau, Oregon transfer Kel'El Ware and freshman Mackenzie Mgbako. It's a White Out at Assembly Hall, where the Hoosiers have won five in a row since a close loss to then-No. 1 Kansas. That's IU's only home loss.
It's a strange season in college hoops, wherein ranked teams have had all sorts of trouble on the conference trail in a strong of upsets. Ask Purdue, already dumped at Northwestern and Nebraska in Big Ten action. IU has proven capable at Assembly Hall, where it just dumped Minnesota on Friday and earlier beat Maryland and Ohio State in league action. Indiana is also one Big Ten team with enough size to battle Zach Edey, as 6-9 PF Malik Reneau (16.3 ppg) and 7-foot Oregon transfer Kel’el Ware (14.8 ppg) are going to make Edey play more defense than usual, and Mike Woodson also very happy with the progress of 6-8 frosh MacKenzie Mgbako, who scored 19 vs. the Golden Gophers on Friday. Play IU