The 2025 College Football Playoff will continue this week with No. 6 Penn State Nittany Lions taking on the No. 7 Notre Dame Fighting Irish in the 2025 Orange Bowl on Thursday in the semifinals. The Fighting Irish are 13-1 on the season and own the nation's longest winning streak (12 games), while the Nittany Lions are 13-2. Notre Dame bested Indiana and Georgia en route to the final four, while Penn State defeated SMU and Boise State.

Kickoff is set for 7:30 p.m. ET at Hard Rock Stadium in Miami Gardens, Florida. The Fighting Irish are two-point favorites in the latest Notre Dame vs. Penn State odds via SportsLine consensus, while the over/under for total points scored is 46.5.

Before you make any Penn State vs. Notre Dame picks or any other college football predictions, you need to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 232-150-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 112.07 units ($11,206.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has locked in a confident against-the-spread pick for Penn State vs. Notre Dame in their Orange Bowl matchup during the 2025 College Football Playoff. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a must-back! You absolutely need to see what it is before locking in any picks of your own.

Who wins Notre Dame vs. Penn State in their Orange Bowl matchup, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 232-150-7, returning $11,207 for $100 bettors, betting on college football since Week 1 of the 2023 season, and find out!