A battle between Big Ten heavyweights is on tap for Saturday with the No. 3 Penn State Nittany Lions (7-0, 4-0) set to host the No. 4 Ohio State Buckeyes (6-1, 3-1) at Beaver Stadium in University Park, Pennsylvania. Both programs have legitimate national championship aspirations. Penn State is undefeated straight up, but is 3-4 against the spread. The Nittany Lions beat Wisconsin 28-13 in their last outing. The Buckeyes lone loss of the season came against No. 1 Oregon. Ohio State beat Nebraska 21-17 last week, and is also 3-4 against the spread. Ohio State leads the all-time series 24-14.

Kickoff in College Station is at noon ET. The Buckeyes are 3-point favorites in the latest Penn State vs. Ohio State odds via SportsLine consensus, while the over/under for total points scored is 47.5. Ohio State is a -162 (risk $162 to win $100) favorite on the money line, with Penn State listed as a +135 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Ohio State vs. Penn State picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, netting a whopping 71.1 units while posting a 191-112-3 record since Week 1 of the 2023 season. All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks is WAY UP!

Now, Kaylor has locked in a confident against-the-spread pick for Ohio State vs. Penn State in their Week 10 Big Ten matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Ohio State vs. Penn State in their Week 10 matchup in Happy Valley on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 191-112-3, returning $7,110 for $100 bettors, betting on college football since Week 1 of the 2023 season, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates