'The Horseshoe' will be the center of the college football world when the No. 3 Ohio State Buckeyes host the No. 7 Penn State Nittany Lions in a battle between Big Ten powerhouses on Saturday. Kickoff is set for Noon ET at Ohio Stadium. Both teams are coming off blowout victories, with the Buckeyes beating Purdue 41-7 and Penn State defeating UMass 63-0. Ohio State is 3-1-1 and Penn State is 5-0 against the spread in 2023. The Buckeyes have defeated the Nittany Lions in six straight meetings.

The Buckeyes are 4.5-point favorites in the latest Penn State vs. Ohio State odds via SportsLine consensus, while the over/under for total points scored is 45. Ohio State is a -185 (risk $194 to win $100) favorite on the money line, with Penn State listed as a +155 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Ohio State vs. Penn State picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has been red-hot all season, going 24-9-1 on his college football best bets for SportsLine this season so far! Anyone who has followed his picks is WAY UP!

Kaylor knows that Penn State is arguably the best defensive football team in college football. The Nittany Lions allow only 193.7 total yards and 8.0 points per game. Penn State also has an extremely talented quarterback in former five-star recruit Drew Allar, who enters this matchup with 12 touchdown passes, three rushing TDs, and no interceptions. 

Kaylor, however, also factored in that Ohio State is once again one of the most talented overall teams in the country. Quarterback Kyle McCord has stepped in nicely for C.J. Stroud, and Marvin Harrison Jr. is perhaps the best player (regardless of position) in college football. The Buckeyes have one of football's best home field advantages at Ohio Stadium. 

Now, Kaylor has locked in a confident against-the-spread pick for Ohio State vs. Penn State. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Penn State vs. Ohio State at Ohio Stadium on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Ohio State vs. Penn State spread to jump on, all from the expert who is on a 24-9 roll betting on college football this season, and find out!