The Week 17 NFL schedule will conclude with the San Francisco 49ers (+3.5, 50.5) hosting the Detroit Lions on Monday Night Football. The 49ers (6-9) have had a disappointing, injury-plagued season, while the Lions (13-2) control their own destiny for home-field advantage in the NFC. However, both teams rank top five in yards per play and NFL daily Fantasy players should benefit from a deeper-than-usual NFL DFS player pool for this single-game slate.

Jameson Williams is coming off a career-high 143 receiving yards in a win over the Bears last week and could be a popular option for NFL DFS lineups. How much exposure should you have to the big-play receiver and who else should you target for 49ers vs. Lions on Monday Night Football? Before making any NFL DFS picks on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is WAY UP!

Now, McClure has turned his attention to Lions vs. 49ers on Monday Night Football and locked in his top daily Fantasy football picks.

We can tell you one of McClure's top NFL DFS picks for Monday Night Football is 49ers tight end George Kittle. He's also targeting Lions running back Jahmyr Gibbs. With David Montgomery (knee) out last week, Gibbs piled up a season-high 27 touches and produced 153 scrimmage yards and a touchdown against Chicago. He notched his third 100-yard rushing game of the year and has now scored 15 total touchdowns in back-to-back seasons.

McClure is also targeting a player who could go off for MASSIVE numbers for Monday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks 49ers vs. Lions, and which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!