Week 15 begins with an NFC West showdown between the San Francisco 49ers (-3, 49) and Los Angeles Rams at 8:15 p.m. ET on Thursday Night Football. The NFL DFS player pool is packed with strong options like Brock Purdy, George Kittle, Cooper Kupp, Puka Nacua and Kyren Williams, so who should daily Fantasy football players include in their NFL DFS picks and NFL DFS stacks? Before setting your NFL DFS lineups on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

Now, McClure has turned his attention to Rams vs. 49ers on Thursday Night Football and locked in his top daily Fantasy football picks.

We can tell you one of McClure's top NFL DFS picks for Thursday Night Football is 49ers quarterback Brock Purdy. Part of McClure's optimal NFL DFS strategy also includes rostering Rams running back Kyren Williams, who had 29 rushing attempts and two touchdowns last Sunday.

McClure is also targeting an undervalued player who could go off for MASSIVE numbers on Thursday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks 49ers vs. Rams? And which under-the-radar player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for sites like FanDuel and DraftKings, and cash in BIG on NFL DFS!