The Week 6 NFL schedule opens with a primetime matchup between the San Francisco 49ers (-3.5, 48.5) and Seattle Seahawks on Thursday Night Football. Kickoff at Lumen Field in Seattle is scheduled for 8:15 p.m. ET. The NFL DFS player pool for TNF is stacked at the skill positions with several high-end, proven fantasy options, mixed with young players who have shined early in their NFL careers. Should daily Fantasy football players include veteran stars like Deebo Samuel, DK Metcalf and George Kittle in NFL DFS lineups? Should you include breakout players like Jordan Mason or Jaxon Smith-Njigba in your Thursday Night Football DFS lineups or NFL DFS stacks? 

Before locking in any NFL DFS lineups or NFL DFS stacks for 49ers vs. Seahawks on Thursday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who cashed big all season in 2022, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor hit on epic NFL DFS picks for SportsLine members throughout the 2022 and 2023 seasons. In 2022, he was all over Travis Kelce's four-touchdown performance against the Raiders on Monday Night Football, Kirk Cousins' 460-yard, four-TD performance on Thanksgiving Day, and T.J. Hockenson's 13 catches for 109 yards and two touchdowns in Week 15. In 2023, he hit on Ja'Marr Chase's massive Week 5 performance (15 catches, 192 yards, three TDs), D.J. Moore's eight catches for 230 yards and three touchdowns in Week 14, and De'Von Anchane's breakout performance (233 total yards, four TD's) in Week 3. Anyone who followed his picks is WAY UP!

This season, in the Sao Paulo game, one of Kaylor's top picks was Green Bay wide receiver Jayden Reed, who caught four passes for 138 yards and a touchdown and rushed for 33 yards and a score. 

Now, Kaylor has turned his attention to Seahawks vs. 49ers on Thursday Night Football and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for 49ers vs. Seahawks is 49ers receiver Deebo Samuel. He's also rostering Seahawks wide receiver Jaxon Smith-Njigba, who had his first touchdown of the season last week and had 19 targets over his last two games. 

Kaylor is also targeting another under-the-radar player who could post HUGE numbers and carry your lineups to victory! His NFL DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups!

What are the top NFL DFS picks for 49ers vs. Seahawks on Thursday Night Football, and which unheralded player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, all from a proven DFS expert who won a Millionaire Maker tournament!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about rosters changes/updates