The Week 15 NFL schedule opens with a primetime matchup between NFC West rivals when the Los Angeles Rams take on the San Francisco 49ers (-2.5, 48.5) on Thursday Night Football. Kickoff at Levi's Stadium in Santa Clara is scheduled for 8:15 p.m. ET. The NFL DFS player pool for TNF is stacked at the skill positions with several high-end, proven fantasy options, mixed with young players who have shined early in their NFL careers. Should daily Fantasy football players include veteran stars like Brock Purdy, Deebo Samuel, George Kittle, Matthew Stafford, Puka Nacua, or Cooper Kupp in NFL DFS lineups? Should you include breakout players like Kyren Williams or Isaac Guerendo in your Thursday Night Football DFS lineups or NFL DFS stacks? 

Before locking in any NFL DFS lineups or NFL DFS stacks for 49ers vs. Rams on Thursday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who cashed big all season in 2022, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor has hit on epic NFL DFS picks for SportsLine members. He was all over slate-breaking performances from players like Travis Kelce (7-25-4), Kirk Cousins (460-4), T.J. Hockenson (13-109-2), Ja'Marr Chase (15-1923), D.J. Moore (8-230-3), and De'Von Anchane (233 total yards, four TDs). This season, some of Kaylor's top picks have included Jayden Reed (4-138-1, 33-1) and James Cook (78-2). Anyone who followed his picks is WAY UP!

Now, Kaylor has turned his attention to 49ers vs. Rams on Thursday Night Football and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for Rams vs. 49ers is Los Angeles wide receiver Puka Nacua. He's also rostering 49ers quarterback Brock Purdy, who faces a Rams defense that just allowed Josh Allen to throw for 342 yards and three touchdowns in Week 14.

Kaylor is also targeting another under-the-radar player who could post HUGE numbers and carry your lineups to victory! His NFL DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups!

What are the top NFL DFS picks for 49ers vs. Rams on Thursday Night Football, and which unheralded player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, all from a proven DFS expert who won a Millionaire Maker tournament!