The Week 17 NFL schedule wraps up with a NFC matchup between the San Francisco 49ers and Detroit Lions (-3.5, 50.5) on Monday Night Football. Kickoff at Levi's Stadium is at 8:15 p.m. ET. The MNF NFL DFS player pool will feature high-end, proven fantasy options, mixed with young, high upside players, meaning there will be plenty of tough decisions to be made when building NFL DFS lineups. Should perennial Pro Bowl candidates like Jared Goff, Brock Purdy, Jahmyr Gibbs, Amon-Ra St. Brown, Deebo Samuel, or George Kittle be part of your Monday Night Football DFS lineups or NFL DFS stacks? Or should you target NFL DFS sleepers like Ricky Pearsall or Isaac Guerendo? 

Before locking in any NFL DFS lineups or NFL DFS stacks for Lions vs. 49ers on Monday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who cashed big all season in 2022, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor has hit on epic NFL DFS picks for SportsLine members. He was all over slate-breaking performances like Travis Kelce's (7-25-4), Kirk Cousins (460-4), T.J. Hockenson's (13-109-2), Ja'Marr Chase's (15-1923), D.J. Moore's (8-230-3), and De'Von Anchane (233 total yards, four TDs). This season, some of Kaylor's top picks include Green Bay wide receiver Jayden Reed (4-138-1, 33-1) and James Cook (78-2). Anyone who followed his picks on sites like DraftKings and FanDuel is way up. Anyone who followed his picks is WAY UP!

Now, Kaylor has turned his attention to Lions vs. 49ers on Monday Night Football and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for Monday Night Football is Lions running back Jahmyr Gibbs. He's also rostering 49ers running back Isaac Guerendo, who set to return from injury on Monday night. 

Kaylor is also targeting another under-the-radar player who could post HUGE numbers and carry your lineups to victory! His NFL DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups!

What are the top NFL DFS picks for Saints vs. Packers on Monday Night Football in Week 16, and which unheralded player is a MUST-ROSTER? ... Join SportsLine now to see the top NFL DFS picks, stacks, and player pools for FanDuel and DraftKings, all from a proven DFS expert who won a Millionaire Maker tournament!