The Week 16 NFL schedule comes to a close with a Monday Night Football matchup between the Los Angeles Chargers (8-6) and Indianapolis Colts (4-9-1) at 8:15 p.m. ET. The Chargers are in the NFL playoffs with a win, while Indy has been eliminated from postseason contention. The Colts will turn to veteran Nick Foles as their third starting quarterback of the season as interim head coach Jeff Saturday looks for some answers in the midst of a four-game losing streak. 

Before locking in any NFL DFS lineups for Monday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who has been cashing big all season, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor has been spot-on all season, hitting on epic NFL DFS picks like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3, 6-106-1, 7-92-1), Amari Cooper (7-101-1, 5-131-1), Nick Chubb (23-113-1, 23-101-2), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1) Cooper Kupp (14-122), Travis Kelce (7-25-4, 10-106), Davante Adams (3-124-2), Justin Fields (179-1-1, 82-1), Derrick Henry (132-2), Jimmy Garoppolo (228-4), Michael Pittman (7-61-1), Christian McCaffrey (26-108-1, 6-30), Kirk Cousins (460-4), Justin Jefferson (12-123-1), J.K. Dobbins (13-125), and T.J. Hockenson (13-109-2). Anyone who has followed his picks is WAY UP!

Now, Kaylor has turned his attention to the Week 16 MNF matchup of Colts vs. Chargers and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for Monday Night Football is Chargers quarterback Justin Herbert. Herbert has cleared 310 passing yards in each of his last three games. And now he takes on a struggling Indianapolis pass defense that got shredded for a whopping 460 passing yards and four touchdowns by Kirk Cousins last week. 

Kaylor is also targeting another under-the-radar player for MNF who could post HUGE numbers and carry your lineups to victory! His NFL DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about rosters changes/updates

What are the top NFL DFS picks for the MNF matchup of Colts vs. Chargers on FanDuel and DraftKings? And which player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, all from a DFS expert who already won a Millionaire Maker tournament in 2022!