Late-season quarterback changes are having a significant impact on the appeal of certain stars in the NFL DFS player pool for Week 16 of the NFL season. The majority of teams who are starting a different quarterback in Week 16 than Week 1 are doing so due to injuries and looking for a spark in a lost season, such as the Cleveland Browns starting Dorian Thompson-Robinson, Tennessee Titans starting Mason Rudolph and the New York Giants without Daniel Jones. 

But the Atlanta Falcons are one game out of first place in the division and switching to Michael Penix Jr., the No. 8 overall pick in the 2024 NFL Draft, to make his debut this weekend, so how should the changes at the most important position in sports affect how daily Fantasy football players making Week 16 NFL DFS lineups? How should this alter the appeal of players like Drake London, Jerry Jeudy, Calvin Ridley and Brian Thomas Jr. when forming an NFL DFS strategy? Before making any Week 16 NFL DFS picks on sites like DraftKings and FanDuel, you NEED to hear what SportsLine daily Fantasy expert Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with SportsLine members. 

His methodology has led to enormous cashes on FanDuel and DraftKings. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is WAY UP!

Now, McClure has turned his attention to the Week 16 NFL main slate and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for Sunday is Lions running back Jahmyr Gibbs ($8,300 on DraftKings and $9,400 on FanDuel). Part of McClure's optimal NFL DFS strategy also includes rostering Arizona Cardinals running back James Conner ($7,100 on DraftKings and $8,400 on FanDuel). The eight-year veteran is averaging 95.3 total yards per game, his most since his second NFL season. Conner rushed for 110 yards and two touchdowns on 16 carries for 6.9 yards per carry and added five receptions for 28 yards against the Patriots last week. The Cardinals play the Panthers, who are allowing most Fantasy football points to opposing running backs this season.

McClure is also targeting a player who could go off for MASSIVE numbers on Sunday! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who they are before locking in any lineups.

What are the top NFL DFS picks for Sunday, and which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!