Week 12 of the 2024 NFL season has some high-impact bye weeks that significantly alter the NFL DFS player pool. With star running backs like Bijan Robinson, Alvin Kamara, Breece Hall and James Cook on bye and Derrick Henry and the Ravens playing on Monday Night Football, who are the top running backs for daily Fantasy football players to target when making main slate NFL DFS lineups for Week 12? Texans running back Joe Mixon was the RB1 in Fantasy football last week, but he plays the Titans, who are allowing the sixth-fewest yards per carry in the league. He won't be cheap for NFL DFS picks, so Mixon may not be worth the price to feature him in your Week 12 NFL DFS strategy. 

Before making any Week 12 NFL DFS picks on sites like DraftKings and FanDuel, you NEED to hear what SportsLine daily Fantasy expert Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with SportsLine members. 

His methodology has led to enormous cashes on FanDuel and DraftKings. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is WAY UP!

Now, McClure has turned his attention to the Week 12 NFL main slate and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for Sunday is 49ers running back Christian McCaffrey ($8,500 on DraftKings and $9,500 on FanDuel). Part of McClure's optimal NFL DFS strategy also includes stacking McCaffrey with 49ers wide receiver Jauan Jennings ($5,600 on DraftKings and $6,700 on FanDuel). Jennings had 10 receptions for 91 yards and a touchdown last week after having seven receptions for 93 yards the week before. He had 11 targets in each contest as he's taking on a primary role in the offense with Brandon Aiyuk (knee) out for the season.

McClure is also targeting a player who could go off for MASSIVE numbers on Sunday! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who they are before locking in any lineups.

What are the top NFL DFS picks for Sunday, and which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!