Led by head coach Deion Sanders and surprise Heisman Trophy candidates Travis Hunter and Shedeur Sanders, the Colorado Buffaloes enter Week 2 of the college football season ranked in the top-25 for the first time since the 2020 season. No. 22 CU will face longtime rival Nebraska in the first home game of the Coach Prime era. Kickoff at Folsom Field in Boulder, Colo. is set for noon ET. Colorado is coming off a massive 45-42 upset over TCU in its season opener. The Cornhuskers are looking to bounce back from a 13-10 season opening loss to Minnesota in their first game under new head coach Matt Rhule. The Buffs are 2.5-point favorites in the latest Colorado vs. Nebraska odds, while the over/under for total points scored is 58 (see up-to-date odds for every game this week on our college football odds page).

Before you make any CU vs. Nebraska picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. Anyone who has followed his picks is WAY UP.

Kaylor knows the talent level has increased dramatically at Colorado. Quarterback Shedeur Sanders broke nine school records in the team's season opener, Travis Hunter inserted himself into the Heisman conversation with an impressive two-way performance, and freshman running back Dylan Edwards scored 4 touchdowns in his collegiate debut.

Kaylor also knows that Nebraska has the potential to be one of the better defensive teams in the Big Ten under first year head coach Matt Rhule. The Huskers came up short against Minnesota in their season opener, but the team's defensive performance offered plenty of reason for optimism heading into Week 2.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. Nebraska. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Colorado vs. Nebraska on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Nebraska vs. Colorado spread to jump on, all from the expert who has been cashing big on Denver area teams all year!