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MLB DFS: Optimal FanDuel, DraftKings picks, player pool, fantasy lineup advice for Monday, April 21, 2025

Daily Fantasy millionaire Mike McClure shares his top MLB DFS picks and stacks for Monday

By@Mike5754Updated: Apr 21, 2025 9:47PM UTC . 3 min read

The Monday MLB schedule features six games that have a first pitch coming after 6:30 p.m. ET, so the main slate has limited options to create MLB DFS lineups from. Nevertheless, big names such as Francisco Lindor, Vladimir Guerrero Jr., Juan Soto and Manny Machado can be utilized in your MLB DFS strategy as daily Fantasy baseball picks.

Before setting your MLB DFS lineups on daily Fantasy sites like DraftKings and FanDuel for Monday, April 21, you NEED to see the top MLB DFS picks from Mike McClure. McClure is a daily Fantasy pro with over $2 million in career winnings

When it comes to MLB, McClure is at his best. Recognized in the book "Fantasy Football (and Baseball) for Smart People: How to Turn Your Hobby into a Fortune," McClure's proprietary MLB DFS projection model simulates each game 10,000 times, taking factors such as matchups and recent results into account. This allows him to find the best values on every site.

On Friday (when he last made picks), McClure identified Giants starter Logan Webb as his top pitcher MLB DFS pick on both sites. The result: Webb struck out 12 over six innings, allowing just one earned run to return 33.1 points on DraftKings and 55 points on FanDuel. Anybody who included him in their lineups could have been well on the way to a profitable day!

One of McClure's top MLB DFS picks for Monday is Braves first baseman Matt Olson at $4,800 on DraftKings and $2,900 on FanDuel for MLB DFS lineups. McClure is stacking Olson with outfielder Michael Harris II ($4,400 on DraftKings and $2,700 on FanDuel). The Braves match up with Cardinals RHP Erick Fedde, and Harris has had considerable success versus Fedde. The outfielder is 3-for-4 in his career against the pitcher, with four RBI and a double.

McClure is also targeting a player who is set to EXPLODE for huge numbers on Monday! The stars are aligning for him to return tournament-winning value, and he comes at a price that won't break the bank. This pick could be the difference between cashing in big or going home with nothing!

What players can you bank on in MLB DFS for Monday, and which undervalued player is a MUST-ROSTER?... Join SportsLine now to see DFS pro Mike McClure's top picks and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!

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