The No. 10 Notre Dame Fighting Irish (5-1) stay on the road to take on the No. 25 Louisville Cardinals (5-0) on Saturday. Kickoff is at 7:37 p.m. ET at Cardinal Stadium. The Irish are looking to build off a come from behind 21-14 win over Duke, while Louisville looks to stay unbeaten after knocking off N.C. State 13-10 last week. Notre Dame will be out to extend its winning streak in regular season games against ACC opponents to 31. Notre Dame and Louisville last played in 2020 with the Irish winning 12-7.

The Irish are 6.5-point favorites in the latest Louisville vs. Notre Dame odds via SportsLine consensus, while the over/under for total points scored is 53.5 and Notre Dame is a -256 favorite on the money line (see up-to-date odds for every game this week on our college football odds page).

Before you make any Notre Dame vs. Louisville picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his football picks for SportsLine in 2023, going 9-1 overall last week and 4-0 in the Notre Dame vs. Duke game, bringing his season record up to 18-3 on his best bets in 2023. Anyone who has followed his picks is WAY UP!

Kaylor knows that Notre Dame is coming off hard fought games in back-to-back weeks. After losing a heartbreaker to Ohio State two weeks ago, the Irish bounced back with a huge win over Duke last Saturday. Veteran quarterback Sam Hartman delivered a clutch fourth quarter performance against Duke that was capped by a 30-yard touchdown run from Auric Estime to secure the win for the Irish. Notre Dame is 3-1-1 against the spread this season.

Kaylor, however, also factored in that Louisville had Hartman's number last season when he was with Wake Forest. The Cardinals picked off three Hartman passes, returning two for touchdowns, in that 48-21 Louisville victory. The Cardinals aren't as battle-tested as the Irish, but first year head coach Jeff Brohm is no stranger to the big stage. 

Now, Kaylor has locked in a confident against-the-spread pick for Notre Dame vs. Louisville. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Notre Dame vs. Louisville at Cardinal Stadium on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Louisville vs. Notre Dame spread to jump on, all from the expert who is on a 18-3 roll this season, and find out!