The Aubrun Tigers will take on the Creighton Bluejays in a South Region matchup in the second round of the 2025 NCAA Tournament bracket on Saturday. Auburn beat Alabama State 83-63 in its first-round win on Thursday. Creighton defeated Louisville 89-75 in the first round to advance to Saturday's matchup. Creighton is 21-13-1 and Auburn is 17-16-1 against the spread this season.

Tipoff from Rupp Arena in Lexington, is set for 7:10 p.m. ET. Auburn is an 8.5-point favorite in the latest Creighton vs. Auburn odds from SportsLine consensus, while the over/under for total points scored is 149.5. 

Before making any Creighton vs. Auburn picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Creighton vs. Auburn 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Creighton vs. Auburn in the 2025 NCAA Tournament, and which side of the spread hits in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!