Colombia hope to set a club record and advance to the final for the first time in more than two decades when they face Uruguay at Bank of America Stadium in Charlotte, NC on Wednesday in the 2024 Copa America semifinals. Colombia, whose most recent final appearance in the tournament came when they won their lone title in 2001, routed Panama 5-0 in the quarterfinals to extend their unbeaten streak across all competitions to 27 contests (21-6-0) - matching the team mark set from 1992-94. Uruguay are even with Argentina at 15 Copa America championships and kept alive their chance to take the all-time lead by defeating Brazil on penalties in the quarters. These sides met in the 2021 quarterfinals, with the Colombians advancing on penalties.

Kickoff is set for 8 p.m. ET. Uruguay are +170 favorites (risk $100 to win $170) in the latest Colombia vs. Uruguay odds via SportsLine consensus, while the Colombians are +220 underdogs. A 90-minute draw is priced at +170 and the over/under for total goals scored is 1.5. Before you lock in your Uruguay vs. Colombia picks or 2024 Copa America predictions, you need to see what soccer bettor Jon "Buckets" Eimer has to say.

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, he has covered the English Premier League, Serie A, the FA Cup and much more. He was red-hot in 2023, going 248-234-12 for a profit of $2,593 for $100 bettors. That included an 86-59-5 record in Premier League picks for a profit of $3,463.

Eimer knows that Colombia have not tasted defeat since Feb. 1, 2022, when they dropped a 1-0 decision to Argentina during 2022 World Cup Qualifying. The club ranks first in Copa America with 11 goals, with forward Jhon Cordoba, defender Daniel Munoz and winger Luis Diaz netting two tallies apiece. Meanwhile, midfielder James Rodriguez has notched a tournament-leading five assists, making him just the second player to reach that amount since the statistic became available in 2011.

The expert also has taken into account that Uruguay have reached the semifinals for the first time since winning their last tournament title in 2011. The Uruguayans are tied for second in the competition with nine goals, all of which they recorded during the group stage. Forward Darwin Nunez and defender Maximiliano Araujo lead the club with two tallies apiece, but the latter will miss the remainder of the tournament with a leg injury he suffered against Brazil in the quarterfinals.

For Wednesday, Eimer has taken an in-depth look at the Colombia vs. Uruguay matchup and is leaning Over on the goal total. He also has released three confident best bets, including two that offer plus-money payouts, and is offering a full breakdown of this 2024 Copa America semifinal match. You ABSOLUTELY need to see his picks and analysis before making any selections of your own. 

Who wins Colombia vs. Uruguay on Wednesday, and what plus-money bet should you jump on NOW? ... Join SportsLine now to see Jon Eimer's picks for Uruguay vs. Colombia, all from the expert who was red-hot in 2023!