No. 16 LSU has had a tumultuous start to the 2024 college football season. After a tough opening night loss to now-No. 11 USC, the Tigers took care of business against Nicholls State. But LSU was taken to the edge by South Carolina in Week 3, with the Tigers needing a touchdown in the final two minutes to seal a 36-33 road win. Week 4 now has the Tigers hosting the UCLA Bruins. LSU is 11-0 in its last 11 games at home, but the Tigers are 0-5 against the spread in their past five games played in September. 

Other notable Week 4 matchups on Saturday include Illinois at Nebraska, USC at Michigan, Utah at Oklahoma State, and Tennessee at Oklahoma. Before you make any Week 4 college football predictions, be sure to checkout the Week 4 college football picks from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

Over the past two college football seasons, Casale is 122-92-5 (57%) overall and 26-8 (76.4%) in bowl games -- all publicly documented. Just last week, Casale advised SportsLine members to back Alabama (-15.5) against Wisconsin. The Crimson Tide easily took care of business with a 42-10 win over the Badgers.

Now, he's turned his attention to the 2024 Week 4 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top three plays.

We can tell you Casale is backing LSU (-21.5) against UCLA on Saturday. "UCLA is one of the worst Power 4 teams in the country this season," Casale said.

Casale has also found two other college football picks he loves, including backing an overlooked team that "excels in the underdog role." You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 4 in the 2024 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation!