The college basketball season tipped off back on Nov. 4. Now we are down to the final 16 teams. 

Each tournament is different. This tournament is where lower seeds go to die. The only double-digit seed to make the Sweet 16 is Arkansas (10). Seven of the eight No. 1 and No. 2 seeds remain in the field, with St. John's the only to get knocked off. The SEC was considered the best conference all season and it put a record seven teams in the Sweet 16.

So March hasn't been all that mad in 2025. With most of the top seeds making the Sweet 16 though, it sets up for some intriguing matchups on Thursday and Friday. Here is how I recommend approaching the Sweet 16 from a betting perspective. 

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

He's done well in college basketball, going 341-208 (62.1%) over the last three campaigns. He joined SportsLine in 2024 and promptly went 28-14-1 (67%) in college basketball picks, returning $1,215 to $100 players. He's now 60-36 (+1828) in his last 96 official college basketball plays on SportsLine. Anybody who's followed his advice is WAY UP!

Casale shares his strategies for how to bet on the Sweet 16, including whether he traditionally backs favorites or underdogs in this round. You ABSOLUTELY NEED to read what he has to say before locking in more 2025 NCAA Tournament picks.

So how should you be betting on the Sweet 16? Join SportsLine right now to see Casale's expert strategy, all from a red-hot college basketball expert that is on a 60-36 (+1828) run on his NCAA hoops picks!