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2025 NCAA Tournament Cinderella picks: Best darkhorse teams to make a bracket-busting run to Final Four

SportsLine expert Thomas Casale, who's on an incredible 57-32 run with his official CBB picks, shares his top Cinderella pick in each region.

The popularity of the NCAA Tournament over the years has been built on upsets, buzzer beaters and one word… Cinderella. 

There is nothing like picking a No. 13 seed to make the Sweet 16 or betting the money line on a No. 12 seed in the first round and being right. Two years ago, we saw a tournament dominated by Cinderellas when lower seeds Miami, San Diego State and Florida Atlantic all made the Final Four. Last year we didn't see a ton of upsets but Cinderella struck again with No. 11 seed NC State reaching the Final Four. 

Identifying the right Cinderella can be profitable for sports bettors as well. A lot of people like to bet on a team to win the National Championship, although wagering on a lower seed to make the Final Four is another way to make a profit. 

Here are teams in each region that have the ingredients to make a surprise run in the NCAA Tournament and be this year's Cinderella. 

Which teams have what it takes to make a Cinderella run into the Final Four? And which No. 11 seed could make a deep run? Join SportsLine right now to see the top Cinderella picks from each region, all from the expert who is on a 57-32 ATS run at SportsLine!

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Thomas Casale
Thomas CasaleCasale on Campus

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