The Creighton Bluejays can advance to the Elite Eight for just the second time in program history when they take on the Princeton Tigers in a Sweet 16 matchup on Friday at the KFC Yum! Center in Louisville, Ky. The last time Creighton reached the Elite Eight of the NCAA Tournament came in 1941 when the field comprised just eight teams. The Bluejays (23-12) enter Friday's game after an 85-76 victory over third-seeded Baylor. Meanwhile the No. 15 seed Tigers (23-8) are the Cinderella team of the tournament after knocking off No. 2 seed Arizona and No. 7 seed Missouri in the first two rounds.

Tipoff is set for 9 p.m. ET. The Bluejays are favored by 10 points in the latest Creighton vs. Princeton odds, while the over/under for total points scored is 141.

Before making any Princeton vs. Creighton picks or 2023 NCAA Tournament predictions, you need to check out the predictions from SportsLine's No. 1 college basketball expert, Larry Hartstein.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He also has been SportsLine's most profitable college basketball expert. In his last 182 college basketball picks, he has gone 103-78-1, which translates to a $1,725 return for $100 bettors.

Hartstein knows that Creighton has a dominant big man in Ryan Kalkbrenner. A 7-foot-1, 260-pound center from Florissant, Mo., Kalkbrenner averages 15.7 points, 6.2 rebounds and 2.2 blocks per game. He also leads the country in field goal percentage (70.6).

Hartstein also has taken into account that Princeton has played excellent defense in the NCAA Tournament. The Tigers are giving up just 59.0 points per game during the tournament, which ranks seventh in the 68-team field. In the first round, they allowed Arizona to score just 55 points and shoot just 3-of-16 from the 3-point line.

For Friday, Hartstein has set his sights on the Sweet 16 and Creighton vs. Princeton. We can tell you that he's leaning Over the total, and he also has discovered a crucial x-factor that makes one side of the spread a must-back. You ABSOLUTELY need to see his pick before locking in any 2023 NCAA Tournament picks of your own.

Who wins Creighton vs. Princeton on Friday? And what x-factor makes one side a must-back? ... Join SportsLine now to see who covers Princeton vs. Creighton, all from SportsLine's No. 1 college basketball expert who has returned $1,725 on his last 182 college basketball picks.