Two of the top four teams in Serie A collide Wednesday as league-leading Napoli visit fourth-place AC Milan for the first leg of their 2022-23 UEFA Champions League quarterfinal matchup. Napoli, who own a 16-point advantage atop the Serie A table, posted a 5-0-1 record during the group stage before rolling past Eintracht Frankfurt in the Round of 16. Seven-time Champions League-winning AC Milan eked past Tottenham in the first knockout round after going 3-1-2 in group play. The sides split their two league meetings this season, with each winning on the road.

Kickoff at Stadio Giuseppe Meazza is set for 3 p.m. ET. AC Milan are the +160 favorites (risk $100 to win $160) in the latest Napoli vs. AC Milan odds from Caesars Sportsbook, while Napoli are +185 underdogs. A 90-minute draw is priced at +205 and the over/under for total goals scored is 2.5. (For more soccer coverage, click here)

Before you make any AC Milan vs. Napoli picks or UEFA Champions League predictions, you NEED to see what SportsLine soccer insider Martin Green has to say.

After working in the sports betting industry for several years, Green became a professional sports writer and handicapper and has covered the game worldwide. Since last year's World Cup, Green is 77-81-3 (+4.32 units) with his soccer picks, including a 12-8 record (+2.17) with his Champions League predictions.

Now he's locked in on this Napoli vs. AC Milan matchup and revealed his best bets. 

Green knows Napoli have a potent offense as they lead the Champions League with 25 goals. However, the Blues are expected to be without 24-year-old Nigerian forward Victor Osimhen, who is one of four players with four goals after netting three of the team's five tallies in the Round of 16 tie against Eintracht Frankfurt. He leads Serie A with 21 tallies but is dealing with a thigh injury. Georgian winger Khvicha Kvaratskhelia, who has recorded 12 goals and leads the Italian league with 10 assists, has produced two tallies and four assists in the UCL.

The expert also has taken into account that AC Milan's defense has been stellar of late as the team has posted a clean sheet in each of its last four Champions League matches and both of its past Serie A contests - including a 4-0 victory on Apr. 2 against Napoli. Portuguese forward Rafael Leao, who leads the Red and Blacks with 10 goals in league play, recorded a brace in that encounter. French striker Olivier Giroud has netted a team-best four tallies in the Champions League while Spanish forward Brahim Diaz produced Milan's lone goal of their Round-of-16 matchup against Tottenham.

Now, Green has taken an in-depth look at the Napoli vs. AC Milan match from every angle. We can tell you he leaning Over on the goal total, and he has two other CONFIDENT best bets, in addition to a full breakdown of the match. You ABSOLUTELY need to see his picks and analysis before making any selections of your own. 

Where does all the betting value lie for Napoli vs. AC Milan in Wednesday's UEFA Champions League match? ... Join SportsLine now to see Martin Green's best bets for AC Milan vs. Napoli, all from the soccer insider who knows the sport inside and out!