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This appears to be a pitching mismatch between Cubs ace Marcus Stroman (2.29 ERA) and Jake Irvin in his big-league debut. It's not as if Irvin is a top prospect for Washington as the 26-year-old right-hander had a 5.64 ERA and 1.54 WHIP this year at Triple-A Rochester. The Nats used all their key relievers in Tuesday's win so some of them may not be available if relevant. This might get rained out.
The Cubs have a huge starting pitching advantage in this matchup. They will roll with Marcus Stroman, who has a 1.05 WHIP and has allowed two or fewer runs in five of his six starts. Taking the mound for the Nationals will be Jake Irvin, who had never pitched above Double-A prior to this year. Over his five starts at Triple-A, he has a 5.64 ERA and a 1.54 WHIP. There is a lot of juice here, but this is still a prime spot for the Cubs to get a win.