NFL schedule 2021: Odds, expert picks, predictions, best bets, lines, TV coverage for Week 2 slate of games

After all of the buildup and anticipation, Week 1 of the 2021 NFL season did not disappoint. With the Las Vegas Raiders surprising come from behind win over the Baltimore Ravens on Monday Night Football, underdogs went a whopping 12-4 against the spread in the first week of the NFL season. Will that trend continue in Week 2? Or will this week tilt more towards the betting favorites?    

The NFL Week 2 schedule features a full slate of games with several intriguing matchups including Cowboys vs. Chargers, where Justin Herbert and Dad Prescott will battle it out; the Titans vs. Seahawks, in a matchup between two teams with Super Bowl aspirations; and Chiefs vs. Ravens on Sunday Night Football, where fans will get to witness another Patrick Mahomes vs. Lamar Jackson shootout. 

Here is a full rundown of the NFL Week 2 slate of games and TV schedule, as well as odds, picks, and predictions for several matchups. 

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

New York Giants vs. Washington Football Team

• Giants vs. Washington date and time: Thursday, September 16 at 8:20 p.m. ET
• Giants vs. Washington spread: Washington -3.5
• Giants vs. Washington over-under: 41
• Giants vs. Washington moneyline: Giants +145, Washington -170
• Giants vs. Washington TV Coverage: NFL Network
  

Expert Giants vs. Washington picks HERE.

Cincinnati Bengals vs. Chicago Bears

• Bengals vs. Bears date and time: Sunday, September 19 at 1 p.m. ET
• Bengals vs. Bears spread: Bears -3
• Bengals vs. Bears over-under: 45
• Bengals vs. Bears moneyline: Bears -150, Bengals +130
• Bengals vs. Bears TV coverage: Fox
  

Houston Texans vs. Cleveland Browns

• Texans vs. Browns date and time: Sunday, September 19 at 1 p.m. ET
• Texans vs. Browns spread: Browns -12.5
• Texans vs. Browns over-under: 48
• Texans vs. Browns moneyline: Browns -650, Texans +450
• Texans vs. Browns TV coverage: CBS

Los Angeles Rams vs. Indianapolis Colts

• Rams vs. Colts date and time: Sunday, September 19 at 1 p.m. ET
• Rams vs. Colts spread: Rams -4
• Rams vs. Colts over-under: 47.5
• Rams vs. Colts moneyline: Rams -200, Colts +170
• Rams vs. Colts TV coverage: Fox
  

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Buffalo Bills vs. Miami Dolphins

• Bills vs. Dolphins date and time: Sunday, September 19 at 1 p.m. ET
• Bills vs. Dolphins spread: Bills -3.5
• Bills vs. Dolphins over-under: 47.5
• Bills vs. Dolphins moneyline: Bills -180, Dolphinss +155
• Bills vs. Dolphins TV coverage: CBS
  

New England Patriots vs. New York Jets

• Patriots vs. Jets date and time: Sunday, September 19 at 1 p.m. ET
• Patriots vs. Jets spread: Patriots -5.5
• Patriots vs. Jets over-under: 43
• Patriots vs. Jets moneyline: Patriots -250, Jets +205
• Patriots vs. Jets TV coverage: CBS

San Francisco 49ers vs. Philadelphia Eagles

• 49ers vs. Eagles date and time: Sunday, September 19 at 1 p.m. ET
• 49ers vs. Eagles spread: 49ers -3.5
• 49ers vs. Eagles over-under: 50
• 49ers vs. Eagles moneyline: 49ers -190, Eagles +160
• 49ers vs. Eagles TV coverage: Fox
  

Las Vegas Raiders vs. Pittsburgh Steelers

• Raiders vs. Steelers date and time: Sunday, September 19 at 1 p.m. ET
• Raiders vs. Steelers spread: Steelers -5.5
• Raiders vs. Steelers over-under: 47
• Raiders vs. Steelers moneyline: Steelers -250, Raiders +205
• Raiders vs. Steelers TV coverage: CBS

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

New Orleans Saints vs. Carolina Panthers

• Saints vs. Panthers date and time: Sunday, September 19 at 1 p.m. ET
• Saints vs. Panthers spread: Saints -3.5
• Saints vs. Panthers over-under: 44
• Saints vs. Panthers moneyline: Saints -200, Panthers +170
• Saints vs. Panthers TV coverage: Fox
  

Denver Broncos vs. Jacksonville Jaguars

• Broncos vs. Jaguars date and time: Sunday, September 19 at 1 p.m. ET
• Broncos vs. Jaguars spread: Broncos -6
• Broncos vs. Jaguars over-under: 45.5
• Broncos vs. Jaguars moneyline: Broncos -270, Jaguars +220
• Broncos vs. Jaguars TV coverage: CBS

Minnesota Vikings vs. Arizona Cardinals

• Vikings vs. Cardinals date and time: Sunday, September 19 at 4:25 p.m. ET
• Vikings vs. Cardinals spread: Cardinals -4.5
• Vikings vs. Cardinals over-under: 51
• Vikings vs. Cardinals moneyline: Vikings +180, Cardinals -220
• Vikings vs. Cardinals TV coverage: Fox
  

Atlanta Falcons vs. Tampa Bay Buccaneers

• Falcons vs. Buccaneers date and time: Sunday, September 19 at 4:25 p.m. ET
• Falcons vs. Buccaneers spread: Buccaneers -12.5
• Falcons vs. Buccaneers over-under: 52
• Falcons vs. Buccaneers moneyline: Falcons +550, Buccaneers -800
• Falcons vs. Buccaneers TV coverage: Fox

Dallas Cowboys vs. Los Angeles Chargers

• Cowboys vs. Chargers date and time: Sunday, September 19 at 4:25 p.m. ET
• Cowboys vs. Chargers spread: Chargers -3
• Cowboys vs. Chargers over-under: 55
• Cowboys vs. Chargers moneyline: Cowboys +140, Chargers -160
• Cowboys vs. Chargers TV coverage: CBS

Tennessee Titans vs. Seattle Seahawks

• Titans vs. Seahawks date and time: Sunday, September 19 at 4:25 p.m. ET
• Titans vs. Seahawks spread: Seahawks -5.5
• Titans vs. Seahawks over-under: 54
• Titans vs. Seahawks moneyline: Titans +205, Seahawks -250
• Titans vs. Seahawks TV coverage: CBS

Kansas City Chiefs vs. Baltimore Ravens

• Chiefs vs. Ravens date and time: Sunday, September 19 at 8:20 p.m. ET
• Chiefs vs. Ravens spread: Chiefs -3.5
• Chiefs vs. Ravens over-under: 55
• Chiefs vs. Ravens moneyline: Ravens +170, Chiefs -200
• Chiefs vs. Ravens TV coverage: NBC

Detroit Lions vs. Green Bay Packers

• Lions vs. Packers date and time: Monday, September 20 at 8:15 p.m. ET
• Lions vs. Packers spread: Packers -10.5
• Lions vs. Packers over-under: 48
• Lions vs. Packers moneyline: Packers -550, Lions +400
• Lions vs. Packers TV coverage: ESPN
  

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.