2022 Super Bowl odds: Patrick Mahomes-led Chiefs, Tom Brady-led Buccaneers favored heading into NFL Week 1

The 2021 NFL schedule opened this week with the Tampa Bay Buccaneers defeating the Dallas Cowboys 31-29 in the NFL Kickoff Game. The Week 1 slate continues on Sunday and the march towards Super Bowl LVI on February 13, 2022 at SoFi Stadium in Los Angeles is officially on. Despite a preseason full of quarterback competitions being settled and breakout Pro Bowl candidates emerging, not a whole lot has changed in the most recent Vegas Super Bowl 56 odds from Caesars Sportsbook. 

The oddsmakers at Caesars list the Kansas City Chiefs at +500 (risk $100 to win $500) and Tampa Bay Buccaneers at +600 as the top Super Bowl 56 contenders heading into Week 1 of the 2021 NFL season. Chiefs quarterback Patrick Mahomes is also favored to take home NFL MVP honors and should benefit from playing behind a rebuilt offensive line, which was an a glaring issue in their embarrassing Super Bowl LV loss to Tampa Bay. Meanwhile, Tom Brady and the Buccaneers were able to bring back all of the key pieces from their 2021 Super Bowl LV championship run, while also adding depth to their roster during free agency and the NFL Draft. 

The Green Bay Packers' Super Bowl 2021 odds had been on and off the board for most of the offseason while the Aaron Rodgers saga played out. Now that the Vegas oddsmakers know he'll be back with Green Bay for another season, the Packers odds to win Super Bowl LVI have been set at +1400, making them one of the league's top Super Bowl contenders. Other teams expected to generate some Super Bowl 56 buzz early in the 2021 NFL season include the Buffalo Bills (+1200), Los Angeles Rams (+1400), Baltimore Ravens (+1400), and San Francisco 49ers (+1400).       

Who wins every NFL game? And which teams will sink your bankroll? Check out the latest Super Bowl LVI odds from Caesars Sportsbook below, then join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.

Super Bowl 2022 odds, favorites, top contenders (via William Hill):

Chiefs +500 
Buccaneers +600 
Bills +1200 
Ravens +1400 
Rams +1400 
49ers +1400 
Packers +1400 
Browns +1600 
Seahawks +2500
Titans +2500
Saints +3000 
Cowboys +3000 
Dolphins +3000
Patriots +3000 
Chargers +3000
Colts +3500  
Broncos +4000 
Steelers +4000 
Cardinals +4000 
Vikings +4000  
Bears +5000 
Washington Football Team +5000
Falcons +6000
Panthers +8000 
Raiders +8000 
Giants +8000 
Eagles +8000 
Bengals +12500 
Jaguars +12500 
Jets +12500 
Lions +20000 
Texans +25000