The New York Yankees and Cleveland Guardians will close their three-game series in Cleveland on Wednesday afternoon as the Guardians look to complete the sweep. Cleveland is coming off a 3-2 win over the Yankees on Tuesday after winning 6-4 on Monday. The Guardians improved to 14-9 overall this season and have won five straight games. The Yankees fell to 14-10 overall this season. 

First pitch from Progressive Field in Cleveland, Ohio, is set for 1:10 p.m. ET. New York is a -158 favorite on the money line (risk $158 to win $100) in the latest Yankees vs. Guardians odds, while Cleveland is a +133 underdog. The over/under is 8.5 in the latest MLB odds via SportsLine consensus.

Before making any Yankees vs. Guardians picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 5 of the 2025 MLB season on a 13-6 run on top-rated MLB picks (+415). Anybody following could have seen strong returns!

The model has simulated Yankees vs. Guardians 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line is the better value!

Who wins Yankees vs. Guardians, and which side of the money line is the better value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 13-6 roll on top-rated MLB picks!