Yankees vs. Guardians line, odds, start time, pick, best bets for April 22 matchup from proven model
SportsLine's projection model, which is on a profitable 13-6 run, has locked in its MLB picks for the Cleveland Guardians vs. New York Yankees at Progressive Field on Tuesday
The New York Yankees and Cleveland Guardians will continue their three-game series in Cleveland on Tuesday after the Guardians defeated the Yankees 6-4 on Monday in the series opener. Cleveland improved to 13-9 overall this season and has won four straight games. The Yankees fell to 14-9 overall this season.
First pitch from Progressive Field in Cleveland, Ohio, is set for 6:10 p.m. ET. Cleveland is a -115 favorite on the money line (risk $115 to win $100) in the latest Yankees vs. Guardians odds, while New York is a -105 underdog. The over/under is 8.5 in the latest MLB odds via SportsLine consensus.
Before making any Yankees vs. Guardians picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 5 of the 2025 MLB season on a 13-6 run on top-rated MLB picks (+415). Anybody following could have seen strong returns!
The model has simulated Yankees vs. Guardians10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line is the better value!
Who wins Yankees vs. Guardians, and which side of the money line is the better value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 13-6 roll on top-rated MLB picks!
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