The Wild Card Weekend NFL schedule marks the beginning of the 2025 NFL playoffs, with six games taking place. There are a pair of AFC games on Saturday, as the Texans (+3, 42.5) will host the Chargers and the Ravens (-9.5, 44) will host the Steelers in the Wild Card Weekend NFL odds. Sunday's slate features the Bills vs. Broncos (+8.5, 47), Eagles vs. Packers (+4.5, 45.5), and Buccaneers vs. Commanders (+3, 50.5). The opening round of the playoffs concludes with a Monday Night Football showdown between the Rams (+1.5, 47.5) and Vikings.  

Before placing your Wild Card Weekend NFL bets and NFL parlay picks, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2025 NFL playoffs on a 31-14 hot streak on top-rated NFL picks this year -- a stunning 69% success rate. Longer term, it is on a 211-142 roll on top-rated NFL picks that dates back to the 2017 season and a 65-35 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following could have seen huge returns.

Now, it has simulated every snap of 2025 Wild Card Weekend and has revealed its best parlay picks. The five-team parlay could lead to a huge 25-1 payout!

One part of the NFL Wild Card Weekend parlay we can reveal: The model says the Buffalo Bills (-8.5, 47) cover against the Denver Broncos on Sunday (1 p.m. ET). Buffalo was able to rest its starters against New England in Week 18 after clinching the No. 2 seed in the AFC with a three-game winning streak prior to that loss. The Bills have one of the most explosive offenses in the NFL, so Denver is going to have trouble keeping pace on Sunday afternoon. The model shows Buffalo covering in well over 50% of simulations, making it one of its strongest Wild Card Weekend NFL picks. Confidently lock the Bills in as a key part of your Wild Card Weekend NFL parlay picks.

The model also jumped on four other NFL matchups where it says the line is way off, including a pair of underdogs that nearly win outright! You ABSOLUTELY need to see who to pick before locking in any NFL parlays.

Which matchups should you target for your Wild Card Weekend NFL parlay picks, and which teams should you include for an epic 25-1 payout? ... Join SportsLine here to see which teams cover the spread, all from the model that has returned well over $7,000 on its top-rated NFL picks!