Week 6 of the 2021 NFL schedule is highlighted by high profile inter-conference matchups like Arizona at Cleveland, Seattle at Pittsburgh and Dallas at New England. Before you lock in your Week 6 NFL picks and NFL parlays, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has simulated every snap of Week 6 of the 2021 NFL season and has revealed its best parlay picks. The five-team parlay could lead to a HUGE 25-1 payout!

One part of the five-team parlay we'll give away: The Patriots (+4) cover at home against the Cowboys in a matchup between two of the league's most popular teams. The model says New England covers the spread in 60 percent of simulations, making it one of its strongest NFL picks of the week. Confidently lock that in as a key part of your Week 6 NFL parlays.

The model also jumped on four other matchups where the line is WAY off, including a divisional battle and a game between two playoff teams from a season ago! You ABSOLUTELY need to see who it is before locking in any NFL parlays.

So which teams win and cover every game this week? And which team is a MUST-BACK for an epic 25-1 payout? ... Join SportsLine here to see which teams cover the spread, all from the model that has returned almost $7,900 on its top-rated picks!