Week 18, 2025 NFL odds, line, spreads: Proven computer model reveals top NFL parlay picks
The Week 18 NFL schedule marks the end of the 2024-25 regular season and features multiple matchups with playoff implications. The Denver Broncos will try to clinch the final wild-card spot in the AFC when they host the Kansas City Chiefs on Sunday. Kansas City is resting its star players, so the Broncos are 10.5-point favorites in the Week 18 NFL odds.
In the NFC, the Buccaneers (-14.5, 44.5) can clinch the NFC South with a win over the Saints or a Falcons loss to the Panthers. The schedule concludes when the Lions (-3, 56.5) host the Vikings in a game that determines the NFC North title and the No. 1 seed in the NFC.
Before placing your Week 18 NFL bets and NFL parlay picks, you NEED to see what the SportsLine Projection Model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 of the 2024 NFL season on a 30-14 hot streak on top-rated NFL picks this year -- a stunning 68% success rate! Longer term, it is on a 210-142 roll on top-rated NFL picks that dates back to the 2017 season and a 64-35 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!
Now, it has simulated every snap of Week 18 of the 2024 NFL season and has revealed its best parlay picks. The five-team parlay could lead to a HUGE 25-1 payout!
One part of the Week 18 NFL parlay we can reveal: The model says the New Orleans Saints (+14.5, 44.5) cover against the Tampa Bay Buccaneers. New Orleans is coming off a pair of blowout losses, but its previous six games had resulted in wins or single-digit losses. Tampa Bay is dealing with all the pressure in this matchup, as the Buccaneers need a win to guarantee a playoff spot. The model shows New Orleans covering in almost 60% of simulations, making it one of its strongest Week 18 NFL picks. Confidently lock the Saints in as a key part of your Week 18 NFL parlay picks.
The model also jumped on four other NFL matchups where it says the line is WAY OFF, including an A-rated pick in the Lions vs. Vikings game! You ABSOLUTELY need to see who to pick before locking in any NFL parlays.
Which matchups should you target for your Week 18 NFL parlay picks, and which teams should you include for an EPIC 25-1 payout? ... Join SportsLine here to see which teams cover the spread, all from the model that has returned well over $7,000 on its top-rated NFL picks!
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