The San Francisco 49ers have lost four of their last five games, which included a 12-6 setback against the Los Angeles Rams at home last week. The 49ers will try to bounce back and keep their slim playoff hopes alive when they visit the Miami Dolphins on Sunday. San Francisco is 1-6 against the spread in its last seven games on the road and a 1.5-point underdog in the Week 16 NFL odds after the line opened at San Francisco -2. Other notable Week 16 NFL spreads include Lions vs. Bears (+7, 46.5), Rams vs. Jets (+3, 47), and Eagles vs. Commanders (+3.5, 45.5). 

SportsLine's advanced NFL model has revealed its exact NFL score predictions for every game of Week 16, which could mean a HUGE payday of well over 100-1 if any of them hits. Before you lock in any Week 16 NFL picks, make sure you see what SportsLine's advanced computer model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2024 NFL season on an incredible 27-11 hot streak on top-rated NFL picks this year. Longer term, it is on a 207-139 roll on top-rated NFL picks that dates back to the 2017 season and a 61-32 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 16 of the 2024 NFL season, and the results are in.

We can tell you SportsLine's model likes the Tampa Bay Buccaneers (-4, 48.5) to beat the Dallas Cowboys, 28-22, on the road. The Buccaneers will enter Sunday's showdown full of confidence after securing a dominant 40-17 victory on the road against the Los Angeles Chargers last week. Tampa Bay is now 8-1 in its previous nine games played in December. Meanwhile, the Cowboys are 1-8 against the spread in their last nine games at home. The model projects Baker Mayfield will throw for 282 yards and 2.08 touchdowns, while Tampa Bay's defense racks up 2.56 sacks on average.

In addition, the model is calling for multiple underdogs to pull off SHOCKING upsets! Nailing these results is key to making profitable Week 16 NFL picks. You ABSOLUTELY NEED to see who to pick before locking in any Week 16 NFL score predictions!

What are the projected scores for every Week 16 NFL game, and which underdogs shock the NFL? ... Join SportsLine now to get NFL Week 16 score predictions, all from the model on a dominant 61-32 roll!