The Week 16 NFL schedule features games on Saturday and Sunday, with both games on Saturday taking place between playoff contenders. Houston is a 2.5-point road favorite at Kansas City, while Baltimore is a 6.5-point home favorite against Pittsburgh. The slate continues Sunday with matchups like the Eagles (-3.5) at Commanders and Dolphins (-1.5) vs. 49ers. 

Other key matchups this weekend include the Seahawks (+4) vs. Vikings and Cowboys (+4) vs. Buccaneers. The schedule concludes when the Packers (-13.5, 42) host the Saints on Monday Night Football in a game that features one of the larger NFL spreads of the week.

Before placing your Week 16 NFL bets and NFL parlay picks, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2024 NFL season on an incredible 27-11 hot streak on top-rated NFL picks this year. Longer term, it is on a 207-139 roll on top-rated NFL picks that dates back to the 2017 season and a 61-32 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

Now, it has simulated every snap of Week 16 of the 2024 NFL season and has revealed its best parlay picks. The five-team parlay could lead to a HUGE 25-1 payout!

One part of the Week 16 NFL parlay we can reveal: The model says the Washington Commanders (+3.5, 45.5) cover against the Philadelphia Eagles. Washington returned from its bye week with a 20-19 win at New Orleans, giving the Commanders a two-game winning streak heading into this divisional showdown. They were only 4.5-point underdogs at Philadelphia last month, suggesting that there has been an overreaction heading into the rematch at home. The model shows Washington covering in well over 50% of simulations, making it one of its strongest Week 16 NFL picks. Confidently lock the Commanders in as a key part of your Week 16 NFL parlay picks.

The model also jumped on four other NFL matchups where it says the line is WAY OFF, including two underdogs that win outright, defying oddsmakers everywhere! You ABSOLUTELY need to see who to pick before locking in any NFL parlays.

Which matchups should you target for your Week 16 NFL parlay picks, and which teams should you include for an EPIC 25-1 payout? ... Join SportsLine here to see which teams cover the spread, all from the model that has returned well over $7,000 on its top-rated NFL picks!