The expansion of the College Football Playoff to 12 teams has helped ratchet up the intensity of the regular season. The Week 13 college football schedule will once again feature multiple games with serious CFP implications. No. 5 Indiana is unbeaten but will face its first true test when it visits No. 2 Ohio State. The CFP committee is likely to be watching closely this week to see how well the Hoosiers hold up. Meanwhile, No. 14 BYU likely has no room for error coming off a loss to Kansas, and No. 21 Arizona State still has hopes of sneaking into the Big 12 title game and then the CFP.

The latest Week 13 college football odds list Ohio State as a 10.5-point favorite, while BYU is a 3.5-point underdog. Which side should you back in those games, and how should you handle every Week 13 college football spread? Before making any Week 13 college football picks, be sure to check out the college football score predictions from the SportsLine AI PickBot.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has nailed 2,029 4.5- and 5-star NFL prop picks since the start of last season! Anyone who has followed it is WAY UP!

Now, it has turned its attention to the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 13 game, and the results are in. 

We can tell you the AI PickBot likes No. 11 Miami (-23.5, 68.5) to cover comfortably at home against Wake Forest in a noon ET kickoff on Saturday. The Hurricanes are coming off a devastating loss to Georgia Tech that might leave them needing some help to make the College Football Playoff but Miami is a tough matchup for a Wake Forest defense that ranks 114th in the nation in points allowed. Cam Ward has thrown for 3,494 yards and accounted for 35 touchdowns in 10 games this season and the Demon Deacons give up 281.9 passing yards per game. AI PickBot rates Miami to cover as an A+ pick, predicting a 48-19 win.

The AI PickBot has also made exact score predictions in every other FBS matchup, including another 10 A-rated spread picks!

So what are the scores for every college football game in Week 13, and which A-rated spread picks should you be all over? ... Join SportsLine now to see who wins and covers every single game, all from the AI model that has nailed 2,029 of its top-rated NFL prop picks since its inception! ... You've unlocked our best deal! Get your first month of SportsLine for ONLY $1 with the promo code "LEAGUE"! Join here!