The San Francisco 49ers were one of the top 2025 Super Bowl contenders, but they are just 5-5 entering the Week 12 NFL schedule. They are coming off a 20-17 loss to Seattle as six-point home favorites, falling into a three-way tie for second place behind Arizona in the NFC West standings. San Francisco travels to Green Bay on Sunday in one of the must-see games of the week, with the Packers listed as 5.5-point favorites in the Week 12 NFL odds. The 49ers will be without quarterback Brock Purdy (shoulder).

Meanwhile, the Seahawks (-1, 47.5) will host the Cardinals on Sunday, as Arizona tries to maintain its spot atop the division. The Rams (+3, 49) face the Eagles on Sunday Night Football, while the Chargers (+2.5, 50.5) host the Ravens on Monday Night Football in a game with one of the slimmest NFL spreads of the week.

Before placing your Week 12 NFL bets and NFL parlay picks, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2024 NFL season on an incredible 20-8 hot streak on top-rated NFL picks this year. Longer term, it is on a 200-136 roll on top-rated NFL picks that dates back to the 2017 season and a 54-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

Now, it has simulated every snap of Week 12 of the 2024 NFL season and has revealed its best parlay picks. The five-team parlay could lead to a HUGE 25-1 payout!

One part of the Week 12 NFL parlay we can reveal: The model says the Detroit Lions (-7.5, 50.5) cover against the Indianapolis Colts. Detroit has won eight straight games and nine of its first 10 games in a season for the first time since 1934 after crushing Jacksonville in a 52-6 win last week. The Lions set a franchise record for total yards (645), which were the third most in the NFL in the last 20 years. The model shows Detroit covering in almost 60% of simulations, making it one of its strongest Week 12 NFL picks. Confidently lock the Lions in as a key part of your Week 12 NFL parlay picks.

The model also jumped on four other NFL matchups where it says the line is WAY OFF, including an underdog that wins outright! You ABSOLUTELY need to see who to pick before locking in any NFL parlays.

Which matchups should you target for your Week 12 NFL parlay picks, and which underdog should you include for an EPIC 25-1 payout? ... Join SportsLine here to see which teams cover the spread, all from the model that has returned well over $7,000 on its top-rated NFL picks!