The Detroit Lions are one of the NFL's hottest teams, winning six consecutive games. The Lions are also 7-1 against the spread this season, but they'll be tested when they visit the Houston Texans on Sunday Night Football. The Lions are 3.5-point favorites in the Week 10 NFL odds after the line opened at Houston -1.5. Other notable NFL spreads on the Week 10 NFL schedule include Steelers vs. Commanders (-2.5, 45), Jets vs. Cardinals (-1.5, 46.5) and Eagles vs. Cowboys (+7.5, 43.5).

SportsLine's advanced NFL model has revealed its exact NFL score predictions for every game of Week 10, which could mean a HUGE payday of well over 100-1 if any of them hits. Before you lock in any Week 10 NFL picks, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2024 NFL season on an incredible 14-7 hot streak on top-rated NFL picks this year. Longer term, it is on a 195-136 roll on top-rated NFL picks that dates back to the 2017 season and a 49-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 10 of the 2024 NFL season, and the results are in.

We can tell you SportsLine's model likes the Los Angeles Chargers (-8, 39) to beat the Tennessee Titans, 26-16, at home. The Chargers have won three of their past four games and they enter Sunday's showdown with the NFL's top-ranked scoring defense, allowing just 12.6 points per game. The Titans, meanwhile, are averaging only 17.5 points per game, which ranks 27th in the league. The model is projecting Chargers quarterback Justin Herbert to throw for 223 yards and 1.77 touchdowns, while Los Angeles' defense records 3.49 sacks on average.

In addition, the model is picking a home underdog to pull off a shocking upset on Sunday, making it a MUST-BET! Nailing this result is key to making profitable Week 10 NFL picks. You ABSOLUTELY NEED to see which games they are before locking in any Week 10 NFL score predictions!

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What are the scores for every Week 10 NFL game, and which surprising underdog pulls off a SHOCKING upset? ... Join SportsLine now to get the model's NFL Week 10 score predictions, and remember to use the promo code "BLOOM" to get your first week, ALL of the model's Week 10 picks, FREE!