Week 10 College Football odds, predictions: Parlay picks, best bets for SEC, Big Ten, ACC, Big 12, Pac-12 for the weekend of November 5th, 2022

I'll be perfectly honest... last Saturday wasn't the best for my picks. I went 6-9 against the spread and now sit two games under .500 for the season with three successful conference parlay hits. But of those six wins, I definitely achieved the most lucky, fortunate, crazy one I think I've ever witnessed. No, it wasn't the 45-point fourth quarter to hit the seemingly improbable Ohio State-Penn State over. It definitely wasn't the Georgia Tech-Florida State ending, where down 31, GT scored on the final play only to not try a conversion and therefore I lost my +24. Or Michigan, who won by 22 when the line was 22.5. TCU's touchdown in the final two minutes against West Virginia was up there as a fortunate win for the Over and a killer beat for Under backers, but doesn't qualify as one of my all-time favorite betting moments like this next one.

Wake Forest vs. Louisville. October 29th, 2022. A game I won't soon forget. For the purposes of this column, I had Over 62. When betting the game in multiple parlays, I had Over 64 and Over 65.5. After a 6-0 first quarter and 14-13 score at halftime, I wasn't feeling great. Then somewhat miraculously, Louisville forced six turnovers in the third quarter alone! Louisville scored five touchdowns in those 15 minutes and led comfortably, 48-14, heading into the fourth. One more touchdown was all I needed to not push on the SportsLine pick and to hit those parlay picks. Seemed pretty easy for me at this point.

The Demon Deacons took their first drive of the fourth quarter with a backup quarterback. Mitch Griffis, now in the game replacing Sam Hartman, marched his team all the way to the Cardinals' 22 yard line before a fourth-down sack and fumble resulted in yet another turnover. Louisville wasted a bunch of time and finally turned it over on downs at the Wake 30 with less than six minutes to play. Griffis led the Deacons to the Louisville 14 yard line with 1:16 to play. Fourth-and-6. I needed a conversion to keep hope alive. And just my luck, Griffis threw an interception to the Cardinals' Quincy Riley, who already had a pick-six earlier in the half. Game over, right? Watch the play here to see how this unfolded.

After intercepting the ball near the goal line, Riley evaded a tackle and inexplicably kept running around. Backwards, forwards, sideways but he refused to give himself up. Miraculously at his own 11 yard line, he fumbled and Wake Forest recovered. Three plays later, with 14 seconds left, Griffis found Trey Boll III for a five yard touchdown. It was a miracle. An all-timer of a betting win. I don't know what Riley was thinking on that play. Why would he try to score again with a minute left all the way across the field? 

I was literally yelling out loud at Arizona Stadium during the pregame festivities of USC-Arizona while watching this on my phone. People around me must've thought I was nuts! Gambling can be so much fun sometimes and other times, it ruins your day. In this case, it went in my favor and won't soon be forgotten!

On to the picks this week and we have the game of the regular season to this point, No. 1 vs. No. 2, Georgia vs. Tennessee. I don't have a strong lean on what looks to be a weird line but I'll make a pick for that one. Il'l also have a pick for the other SEC ranked vs. ranked matchup of Week 10, the usual barnburner between Alabama and LSU. Since apparently I can't pick under lines correctly, we're going overs galore this week.

Once again, the purpose of this column each week is to find the best parlay bets by conference. I'll try to keep each wager between two and four picks, but the combined parlay of my favorite picks at the bottom of the column each week will be our lottery ticket. If we hit even just one of those all season, it should get us a guaranteed season profit.

All lines are from Caesars Sportsbook.

Make sure to check out Wildcat Country, my Arizona Wildcats podcast with co-host Shane Dale! New episodes out weekly.

Get access to all of SportsLine's college football simulations and expert picks! Use promo code LIFETIME to get 50% off a SportsLine annual subscription, only $49.99 a year FOR LIFE!

SEC parlay picks

Kentucky -1.5 at Missouri
Georgia -8.5 vs. Tennessee
LSU +13 vs. Alabama
Parlay Odds: +596 (1 unit)

Kentucky and Missouri are two of the teams that cost me last week, though for different reasons. Kentucky laid an egg against Tennessee and Missouri pulled the surprising road upset at South Carolina. I'm buying into Mark Stoops' formerly top-10 ranked team bouncing back this weekend and winning on the road by at least a touchdown. As I mentioned above, I don't have a strong lean on the Georgia vs. Tennessee game. But I noticed that the Bulldogs have won five straight against the Volunteers, with the closest margin of victory being 23 points. Last year's game was a 24-point blowout. The Bulldogs cement themselves as the nation's No. 1 team with a convincing win on Saturday. Outside of a daytime home thrashing at the hands of Tennessee in early-October, LSU has been outstanding since their opening loss to Florida State. Alabama has two extremely difficult road games in a row, this night game in Death Valley and next week's trip to The Grove at Ole Miss. I have a strange feeling they'll lose one of them and it wouldn't shock me if this was the week. Give me the home 'dog getting nearly two touchdowns.

Game Record: 0-3 last week, 11-15 overall
Conference Parlay Record: 2 of 9 overall (+2.99 units)

BIG TEN parlay picks

Northwestern-Ohio State Over 60.5
Maryland-Wisconsin Over 50.5
Rutgers +26.5 vs. Michigan
Parlay Odds: +596 (1 unit)

Alright class - let's see if we've been paying attention these last few weeks. Ohio State's 44 points against Penn State marked their lowest output since the Week 1 Notre Dame game. Style points matter for the Buckeyes, who have done everything right and still aren't in the top-two of the rankings. Pat Fitzgerald's Wildcats stink, but they should be able to muster a touchdown or two in garbage time to push this one Over. It wouldn't shock me either if Ohio State scored 60+ and hit the total by themselves. Maryland and Wisconsin have played three times between 2014 and 2017 and the Over hit in all three. Now truthfully, that history means nothing when it comes to Saturday -- but in 2022, the Badgers' last six games have all gone Over. We'll continue to ride that trend and continue the theme of a very high-scoring Week 10 in college football. Since he returned to Rutgers in 2020, Greg Schiano's Rutgers teams have lost to Michigan by only six and seven points respectively. The Scarlet Knights are a bad 4-4 team but I think they can keep this one much closer than four touchdowns and likely hold the Wolverines to under 40 points.

Game Record: 1-2 last week, 13-15 overall
Conference Parlay Record: 0 of 9 overall (-10.5 units)

Does the SportsLine model agree with Eric's parlay picks? Find out here and sign up with promo code LIFETIME to receive a SportsLine annual recurring subscription for only $49.99!

ACC parlay picks

Clemson -4 at Notre Dame
Miami +7.5 vs. Florida State
Wake Forest-NC State Over 54
Parlay Odds: +596 (1 unit)

Still not buying much into Notre Dame this season. The road win at UNC was nice, but the home losses to Marshall and Stanford are nausea-inducing for their fans. The Tigers are significantly better than I expected so I'll ride them to a road win by at least a touchdown, even though ND coach Marcus Freeman badly needs this game for his long term job security. I know the Hurricanes are a mess but if anyone understands how important this rivalry is, it's 'Canes coach and former player Mario Cristobal. My parents are UM grads so I grew up idolizing this rivalry. Florida State hasn't beaten the 'Canes by more than a touchdown since 2013. If Miami starting QB Tyler Van Dyke plays, I'd even consider taking the Hurricanes outright. In the matchup of two teams which are ranked but shouldn't be, I'm going to take the Over though it's questionable at best. Here's my logic: the last two years, these teams split though both scores ended up 45-42. Wake Forest's Week 9 struggles were covered above but NC State pulled a rabbit out of their hat against Virginia Tech, rallying behind third-string QB MJ Morris to a 22-21 win over a bad Virginia Tech team. With Morris being able to actually pass the ball, unlike Jack Chambers who came before him (who replaced their really good starter, Devin Leary, who is out for the season), expect the Wolfpack to score in the 20s at least. Look for a fun, back-and-forth game and don't be surprised if NC State pulls the home upset as a 4.5 point underdog as well.

Game Record: 2-1 last week, 12-13 overall
Conference Parlay Record: 0 of 9 overall (-12 units)

BIG 12 parlay picks

Baylor-Oklahoma Over 58.5
Oklahoma State -2 at Kansas
Texas -2.5 at Kansas State
Parlay Odds: +596 (1 unit)

The last five Baylor games have hit the Over. Oklahoma's offense with Dillon Gabriel is dynamic. Their defense though, I'm still not buying into. Let's stick with the trends and hope for both teams to score in the 30s. I used this line last week: "I expect the Cowboys to keep their Big 12 Championship Game hopes alive with a solid road victory." I think picking Oklahoma State over Kansas State was among the worst picks I've ever made. Final score: 48-0 Kansas State. Yikes. Since Kansas' 5-0 start, their season has taken a nosedive with three straight losses, although they have been competitive in all of them. Make it four this week! I'm somehow back on the Oklahoma State train again but if they lose, I'm not touching them again for the rest of 2022. I'm probably foolish for including Texas in this parlay, but I don't get this line. Shouldn't a top-15 team be favored against an unranked team at home? I'm going with the 'someone knows something' approach and taking the Longhorns here.

Game Record: 2-1 last week, 15-11-1 overall
Conference Parlay Record: 0 of 9 overall (-9.5 units)

PAC-12 parlay picks

Oregon-Colorado Over 61
Washington State -5 at Stanford
Arizona +17.5 at Utah
Parlay Odds: +596 (1 unit)

What am I missing here with this Ducks-Buffaloes over line? Oregon games have achieved 61 or more points every time since the 49-3 opening week debacle against Georgia. Colorado is bad, but they should be able to score two touchdowns to put this one Over. The Ducks won't score less than 45 as style points matter (see last week's picks column for more of an explanation). And there are no weather concerns for Saturday in Boulder. My favorite pick of the week: WSU has beaten Stanford five times in a row and needs two more wins for bowl eligibility this season. The Cardinal got their signature win of the season at Notre Dame the other week, but their offense has been invisible since early October. Cougars by double-digits. My Arizona pick isn't just of the homer variety -- their offense is actually 20th in the nation in yards per game (475.6). Sure, the defense is terrible, but I think Arizona finds a way to score at least three TDs. Heck, they hung with USC for the most part last weekend! Last year a bad Wildcats team lost 38-29 against a great Utah team. Even if Utes QB Cam Rising plays, I think the Wildcats can backdoor a cover here.

Game Record: 1-2 last week, 14-13 overall
Conference Parlay Record: 1 of 9 overall (-4.54 units)

Make your own Week 10 college football parlay using SportsLine's expert picks! Use promo code LIFETIME to receive 50% off an annual subscription FOR LIFE!

*Open to new customers or subscribers who canceled prior to August 30th, 2022. This offer (the "Offer") of an annual subscription at $49.99 of SportsLine (regular price of $99.99) begins at 12:01 a.m. ET on August 29th, 2022 and expires at 11:59 p.m. ET on 12/01/22. Offer is not transferable. Valid credit card is required. SUBSCRIPTIONS WILL AUTOMATICALLY RENEW, AND YOUR CARD WILL BE CHARGED $49.99 FOR AN ANNUAL SUBSCRIPTION ON AN ONGOING BASIS UNLESS YOU CANCEL YOUR MEMBERSHIP PRIOR TO YOUR SUBSCRIPTION END DATE. To cancel, call (888) 508-3055 or email support@sportsline.com. Cancellation will be effective at end of then-current subscription period. No refunds. Other restrictions and taxes may apply. Offer may not be combined with any other offers such as extensions or discounts. Offer may be terminated or modified at any time without notice. For more information, see SportsLine Terms of Use.

Week 10 College Football parlay picks

Kentucky -1.5 at Missouri
Northwestern-Ohio State Over 61.5
Clemson -4 at Notre Dame
Miami +7.5 vs. Florida State
Baylor-Oklahoma Over 58.5
Oklahoma State -2 at Kansas
Oregon-Colorado Over 61

Parlay Odds: +9142 (0.5 units)
Weekly Parlay Record: 0 of 9 overall (-4.5 units)

Looking for the best picks against the spread, sharp plays on the total, and props you can take straight to the pay window? Join Jonathan Coachman on the Early Edge as he speaks with SportsLine's top handicappers to preview the day's biggest games. We promise to keep it short, sweet and to put some green in your pocket. Early Edge is in your feed every single day by 11 a.m. ET. Subscribe right here on YouTube to watch daily, plus don't miss the Early Edge specials and live shows!