The 2022 NFL schedule begins with a number of notable storylines. Quarterback Baker Mayfield leads the Carolina Panthers against his former team, the Cleveland Browns, while two of the league's most dynamic quarterbacks, Patrick Mahomes and Kyler Murray, will face off in Arizona. With plenty of exciting storylines and matchups to consider for your Week 1 NFL picks and NFL parlays, you NEED to see what the SportsLine projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.

Now, it has simulated every snap of Week 1 of the 2022 NFL season and has revealed its best parlay picks. The five-team parlay could lead to a HUGE 25-1 payout!

One part of the five-team parlay we can reveal: The Colts (-8) cover on the road against Houston in an AFC South showdown. The model says Indianapolis covers in almost 60 percent of simulations, making it one of its strongest Week 1 NFL picks. Confidently lock that in as a key part of your Week 1 NFL parlays.

The model also jumped on four other matchups where the line is WAY off, including a divisional battle and games between teams looking to get back to the playoffs again this season! You ABSOLUTELY need to see who to pick before locking in any NFL parlays.

So which teams win and cover every game this week? And which team is a MUST-BACK for an epic 25-1 payout? ... Join SportsLine here to see which teams cover the spread, all from the model that has returned over $7,500 on its top-rated picks!