The No. 2 Duke Blue Devils will look to clinch at least a share of the Atlantic Coast Conference regular-season championship when they battle the Wake Forest Demon Deacons Monday. Wake Forest is coming off a 74-71 win over Notre Dame, while Duke crushed Florida State 100-65. The Demon Deacons (20-9, 12-6 ACC), who are tied for fourth in the league, have lost three of their last five games. The Blue Devils (26-3, 17-1), who lead the ACC, have won six in a row and 22 of the past 23.

Tipoff from Cameron Indoor Stadium in Durham, N.C., is set for 7 p.m. ET. Duke is a 19.5-point favorite in the latest Wake Forest vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 144.5. 

Before making any Wake Forest vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 18 of the 2024-25 season on a 221-162 roll (+1895) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Wake Forest vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations.

So who wins Wake Forest vs. Duke, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!