The Notre Dame Fighting Irish and the Virginia Cavaliers will face off in an ACC clash at 7 p.m. ET on Wednesday at John Paul Jones Arena. Virginia is 15-5 overall and 11-0 at home, while Notre Dame is 7-13 overall and 1-4 on the road. Virginia is favored by 13 points in the latest Virginia vs. Notre Dame odds, and the over/under is set at 116 points.

Notre Dame has really struggled as the underdog this season, and are currently 3-10 in that position. Unfortunately for them, betting on the team to lose has been the play so far; bettors who put $100 on that outcome in every game are now up $272.35. Virginia has dominated as the favorite so far this season, and are currently 15-2 when expecting a win.

Before entering any Virginia vs. Notre Dame picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 13 of the 2023-24 season on a 120-78 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 20-7 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model has simulated Virginia vs. Notre Dame 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

So who wins Virginia vs. Notre Dame, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!