The 11th-ranked Louisville Cardinals host the Virginia Cavaliers in an Atlantic Coast Conference matchup on Thursday night in college football Week 11. The Cardinals (8-1, 5-1 ACC) have won all but two games by at least a touchdown, while the Cavaliers (2-7, 1-4) have lost two in a row following a two-game win streak.

Kickoff is set for 7:30 p.m. ET at Cardinal Stadium in Louisville, Ky. The latest Virginia vs. Louisville odds list the Cardinals as 20.5-point favorites, according to the SportsLine consensus, while the over/under for total points scored is 50. Louisville is the -1449 favorite on the money line (head to SportsLine's college football odds page for the latest odds on every game).

Before you make any Louisville vs. Virginia picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows the Cardinals had a slip-up against Pittsburgh but have otherwise been dominant. They have outscored their past two opponents 57-3, while Virginia has allowed at least 24 points in every game. The Cardinals rushed for 231 yards last week against Virginia Tech and now face a Cavs unit yielding 180 yards per game on the ground (115th in FBS).  

The model also has considered that the Cavs pulled off a huge upset of then-No. 10 North Carolina three weeks ago then took Miami to overtime. Quarterback Tony Muskett, who led those two victories, could be back from a high ankle sprain. Anthony Colandrea has started four games and has at least 200 yards passing yards and 30 rushing in his past two starts.

Now, the model has set its sights on Thursday's Virginia vs. Louisville matchup. We can tell you it is leaning Over on the total, and it also says one side of the spread is hitting in over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks!

Who wins the Virginia vs. Louisville ACC matchup on Thursday, and which side of the spread hits over 50% of the time? ... Join SportsLine right now to find out which side of the Louisville vs. Virginia spread you should be all over Thursday, all from the model that's up well over $2,000 on top-rated CFB spread picks!