The Memphis Tigers will take on the Virginia Cavaliers in a holiday battle at 7 p.m. ET on Wednesday at John Paul Jones Arena. Virginia is 6-4 overall and 5-0 at home, while Memphis is 8-2 overall and 2-0 on the road. Memphis is favored by 4 points in the latest Virginia vs. Memphis odds via SportsLine consensus, and the over/under is 129.5 points.

Before entering any Memphis vs. Virginia picks, you'll want to see the college basketball predictions from the advanced computer model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 7 of the 2024-25 season on a 176-128 betting roll (+2066) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps has seen huge returns.

Now, the model has simulated Virginia vs. Memphis 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits in over 70% of simulations. 

So who wins Memphis vs. Virginia? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.