The No. 23 Clemson Tigers will try to bounce back from their loss to Louisville when they face the Virginia Tech Hokies on Saturday afternoon. Clemson likely had its College Football Playoff hopes dashed in last week's loss to the Cardinals, snapping a six-game winning streak. Virginia Tech is also coming off a disappointing loss, as its three-game winning streak came to an end in overtime at Syracuse. 

Kickoff is set for 3:30 p.m. ET on Saturday at Lane Stadium/Worsham Field. Clemson is favored by 6.5 points in the latest Virginia Tech vs. Clemson odds, while the over/under is 53 points, per SportsLine consensus. Before entering any Clemson vs. Virginia Tech picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 18-9 on all top-rated picks over the past six weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has simulated Virginia Tech vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations!

So who wins Virginia Tech vs. Clemson, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!