One team's season will continue in the Sweet 16, and one team's season will come to an end when the Villanova Wildcats and Ohio State Buckeyes collide in a South Region second round game of the 2022 NCAA Tournament on Sunday at PPG Paints Arena in Pittsburgh, Pa. The Wildcats (27-7) advanced to the second round by cruising past Delaware, 80-60, on Friday. Meanwhile the Buckeyes (20-11) beat Loyola Chicago, 54-41, in the first round. 

Tip-off is set for 2:40 p.m. ET. The Wildcats are favored by 4.5 points in the latest Villanova vs. Ohio State odds from Caesars Sportsbook, while the Over-Under for total points scored is 134. (See up-to-date odds for every game this week on our college basketball odds page.)

Before making any Ohio State vs. Villanova picks or NCAA Tournament predictions, be sure to check out what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every Div. I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows that Villanova has a veteran leader in Collin Gillespie. In his fifth season at Villanova, Gillespie ranks fourth in the Big East in scoring, at 15.9 points per game, and leads the conference in 3-point field goal percentage (42.2). For the second consecutive season he is a finalist for the Bob Cousy Award honoring the nation's top point guard.

The model also knows that Ohio State has one of the best players in the conference in E.J. Liddell. The 6-foot-7 junior from Belleville, Ill., is fourth in the Big Ten in scoring (19.6 points per game) and is averaging 2.6 blocks this season, which is tops in the conference. He has scored in double figures in 42 straight games.

Now, the model has set its sights on the NCAA Tournament and Villanova vs. Ohio State. We can tell you it is leaning Over the total, predicting a combined 143 points, and it also says one side of the spread covers in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Villanova vs. Ohio State? And which side of the spread covers in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Ohio State vs. Villanova spread you should be all over Sunday, all from the model on a roll on college basketball picks!