The Villanova Wildcats will play their second game of a three-game season-opening homestand when they host the Columbia Lions on Wednesday night. Villanova opened the year with a 75-63 win over Lafayette, but it failed to cover the spread as an 18-point favorite. Columbia is coming off an 81-78 win at Loyola-Maryland as it goes on the road for the second game in a row. 

Tipoff is set for 7 p.m. ET on Wednesday at Finneran Pavilion on CBS Sports Network. Villanova is favored by 17 points in the latest Villanova vs. Columbia odds, while the over/under is 144.5 points, per SportsLine consensus. Before entering any Columbia vs. Villanova picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters the 2024-25 season on a 153-110 roll (+1891) on all top-rated college basketball picks dating back to 2023. Anyone following has seen huge returns.

The model has simulated Villanova vs. Columbia 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

So who wins Villanova vs. Columbia? And which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.