The Vanderbilt Commodores will aim for their fifth upset win of the season when they face the South Carolina Gamecocks on Saturday afternoon. Vanderbilt is coming off a 17-7 win at Auburn, clinching bowl eligibility and maintaining its impressive season. South Carolina is on a two-game winning streak following its best performance of the season, cruising to a 44-20 win over then-No. 10 Texas A&M. 

Kickoff is set for 4:15 p.m. ET on Saturday at FirstBank Stadium. South Carolina is favored by 6 points in the latest Vanderbilt vs. South Carolina odds, while the over/under is 45 points, per SportsLine consensus. Before entering any South Carolina vs. Vanderbilt picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 18-9 on all top-rated picks over the past six weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has simulated Vanderbilt vs. South Carolina 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread is the better value!

So who wins Vanderbilt vs. South Carolina, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!