Former champions Vasiliy Lomachenko and George Kambosos Jr. will meet on Saturday for the vacant IBF lightweight title. The 12-round battle tops the main card (8 p.m. ET) from RAC Arena in Perth, Australia.

Lomachenko is a -600 favorite (risk $600 to win $100), while Kambosos comes back at +400 (risk $100 to win $400) in the latest Vaisily Lomachenko vs. George Kambosos Jr. odds. The over/under for total round is 10.5, with the Over listed at -400 and the Under at +275. Lomachenko is -180 to win by decision or technical decision. 

Before locking in your George Kambosos vs. Vasiliy Lomachenko picks, make sure you follow the boxing predictions and betting advice from SportsLine analyst Brandon Wise.  

Wise, who is the combat sports editor for CBS Sports, is an experienced and successful boxing analyst. His SportsLine record has been stellar over the past four years and, in March, he called a win in Round 1 for Jake Paul (+200) against Ryan Bourland and also advised SportsLine members to take the Under 1.5 rounds (+120). Anyone who has followed Wise's combat sports picks is WAY UP! 

With Saturday's showdown fast approaching, Wise has studied Vasiliy Lomachenko vs. George Kambosos from every angle and released confident picks on the total rounds completed and method-of-victory props. 

We can tell you he likes the Over 10.5 rounds, and he's also locked in a confident money line and method-of-victory prop! You ABSOLUTELY need to see Wise's picks before making any of your own!

Who wins Vasiliy Lomachenko vs. George Kambosos on Saturday, and which prop is a MUST-BACK? ... Join SportsLine here to see which bets you need to make for Saturday's big fight, all from the accomplished combat sports analyst who just nailed Jake Paul's first-round win!